Tid og sted for prøveforelesning
Torsdag 22. august klokken 09.15; Geitmyrsveien 69 - Auditorium 1
Bedømmelseskomité
- Associate professor, PhD, Martin Andersson
- Leitender Oberassistent, dr. med. MD Marcus Eblenkamp
- Førsteamanuensis dr. odont. Pia Titterud Sunde - komiteleder
Leder av disputas
Instituttleder Jan Eirik Ellingsen
Sammendrag:
The present thesis deals with the application of bone growth promoting biomolecules to commercially available implant surfaces by electrochemical treatment. The hypothesis was that bioactive molecules could improve cell response and bone formation around the implant.
The study was designed to examine the applicability of combining the properties of the statin simvastatin and the antibiotic doxycycline with titanium based dental implants to apply their beneficial effects locally and achieve maximum treatment efficiency.
The study especially demonstrated the efficiency of the process of coating a TiZr implant surface with doxycycline as it was possible to verify the integrity of the molecule on the surface and show its integration into the outer layer of the coin surface. In addition, the in vitro results demonstrated enhanced bioactivity and good bioavailability of the doxycycline coated surfaces after 14 days in comparison to TiZr SBAE, without negative effects on cell viability. Furthermore, doxycycline coated coin surfaces had positive effects on bone formation markers in vivo after 8 weeks of healing time. Higher BMD values and total bone volume were detected in µ-CT after 8 weeks in the doxycycline coated group and showed that the defect healing was most advanced. Therefore, it was concluded that doxycycline coated surfaces positively influenced cell response and bone formation both in vitro and in vivo. The surface holds potential for the application on hard tissue implants in patients with compromised bone structure.