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Saliva forms a complex protein layer on any type of surface that comes in contact with it by a selective process where, depending on the physicochemical properties of the surface (wettability, surface charge, chemical composition), different types of proteins will adsorb. This protein layer, also known as salivary pellicle, exerts several functions, such as protective barrier, lubricant, keeping the hydration in the oral cavity, mineralization/demineralization of teeth.