Janne Elin Reseland

Professor - Faculty of Dentistry

Norwegian version of this page

Email j.e.reseland@odont.uio.no

Phone +47 22852361

Mobile phone +47 91515962

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Visiting address Geitmyrsveien 69 0455 Oslo

Postal address Postboks 1142 Blindern 0318 Oslo

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Positions held

Professor, Department of Biomaterials . From 2007-present.

Head of the Oral Research Laboratory (ORL) at the Institute of Clinical Dentistry, From 2010-present

Higher education and employment history

BE. in Bioengineering, Oslo Ingeniørhøgskole, MSc in Biochemistry, University of Oslo (UiO), Ph.D. in Biochemistry/Physiology, UiO.

Research scientist, Norwegian Food Research Institute, Research fellow at Oslo Biotechnology Centre, UiO, PostDoc fellow at the Institute for Nutrition Research, UiO, Research scientist at the Institute for Nutrition Research, Faculty of Medicine, UiO, Research scientist at the Institute for Clinical dentistry,Faculty of Dentistry, UiO, Assoc. professor at the Institute for Clinical dentistry, Faculty of Dentistry, UiO, Professor in Biomaterials, Department of Biomaterials, Faculty of Dentistry, UiO

Scientific activity

Have been working on different aspects of adipokines, expression and effects, since 1996, and was instrumental in identifying the expression of adipokines (leptin, adiponectin and resitin) in bone. Have been working with primary human bone cells, bone remodelling and quality since 2001.

Supervising

Supervised more than 15 master students at the University of Oslo, and 14 PhD
students and postdocs at the Universty of Oslo

Tags: Physiology; growth hormones, signaling, regulation, Stem cells, Biomineralization, Bone regeneration and remodelling, Craniofacial molecular and developmental biology, Bone functional genomics and proteomics, matrix biology

Vogelaar, Thomas Daniel; Agger, Anne Eriksson; Reseland, Janne Elin; Linke, Dirk; Jenssen, Håvard & Lund, Reidar (2024). Crafting Stable Antibiotic Nanoparticles via Complex Coacervation of Colistin with Block Copolymers. Biomacromolecules. ISSN 1525-7797. doi: 10.1021/acs.biomac.4c00337.
Ulmner, Mattias; Sugars, Rachael; Naimi-Akbar, Aron; Reseland, Janne Elin & Lund, Bodil (2023). General joint hypermobility in temporomandibular joint disease; clinical characteristics, biomarkers, and surgical aspects. Heliyon. ISSN 2405-8440. 9(12). doi: 10.1016/j.heliyon.2023.e23051. Full text in Research Archive Show summary
Objectives: This study aimed at identifying biomarkers in the temporomandibular joint (TMJ) synovial tissue analysing 28 extra cellular matrix proteins in TMJ diseased patients, classified with either general joint hypermobility (GJH) or normal joint mobility (NJM), and to compile clinical and protein characterisation to reveal potential surgical predictive factors. Study design: A prospective observational cohort study including 97 consecutive patients scheduled for TMJ surgery was performed. Joint mobility and several other predefined clinical varivables were recorded. Synovial tissue was harvested during surgery followed by examination using multi-analytic profiling. A multivariate quantile regression model was used for analysis purposes. Results: The GJH/NJM ratio was 2:5. The GJH cohort were younger (P = 0.001) and more likely to be women (P = 0.026) compared to the NJM cohort. None of the protein concentrations could be correlated to joint mobility in the multivariate regression model, but often to the variable TMJ diagnosis. The surgical outcome after the six-month follow-up were equal between GJH and NJM patients. Conclusions: GJH was more common in the study cohort compared to general population frequencies, but GJH was not a negative factor for surgical outcome. Young age and female gender correlated to GJH. No TMJ biomarkers were GJH specific, and the results suggested that TMJ diagnosis more strongly correlated to the protein profile compared to GJH and the other investigated variables.
Reseland, Janne Elin; Heyward, Catherine Anne & Samara, Athina (2023). Revisiting ameloblastin; addressing the EMT-ECM axis above and beyond oral biology. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 11. doi: 10.3389/fcell.2023.1251540. Full text in Research Archive Show summary
Ameloblastin (AMBN) is best characterized for its role in dental enamel formation, regulating cell differentiation and mineralization, and cell matrix adhesion. However, AMBN has also been detected in mesenchymal stem cells in addition to bone, blood, and adipose tissue. Using immunofluorescence in a pilot scheme, we identified that AMBN is expressed in different parts of the gastrointestinal (GI) tract. AMBN mRNA and protein detection in several tissues along the length of the GI tract suggests a role for AMBN in the structure and tissue integrity of the extracellular matrix (ECM). Intracellular AMBN expression in subsets of cells indicates a potential alternative role in signaling processes. Of note, our previous functional AMBN promoter analyses had shown that it contains epithelial–mesenchymal transition (EMT) regulatory elements. ΑΜΒΝ is herein presented as a paradigm shift of the possible associations and the spatiotemporal regulation of the ECM regulating the EMT and vice versa, using the example of AMBN expression beyond oral biology.
Geng, Tianxiang; Zheng, Mengxue; Wang, Yongfeng; Reseland, Janne Elin & Samara, Athina (2023). An artificial intelligence prediction model based on extracellular matrix proteins for the prognostic prediction and immunotherapeutic evaluation of ovarian serous adenocarcinoma. Frontiers in Molecular Biosciences. ISSN 2296-889X. 10. doi: 10.3389/fmolb.2023.1200354. Full text in Research Archive
Yang, Yang; Pullisaar, Helen; Stunes, Astrid Kamilla; Parreiras Nogueira, Liebert; Syversen, Unni & Reseland, Janne Elin (2023). Irisin reduces orthodontic tooth movement in rats by promoting the osteogenic potential in the periodontal ligament. European Journal of Orthodontics. ISSN 0141-5387. 45(6), p. 842–853. doi: 10.1093/ejo/cjad021. Full text in Research Archive
Munir, Arooj; Reseland, Janne Elin; Tiainen, Hanna; Haugen, Håvard Jostein; Sikorski, Pawel & Christiansen, Emil [Show all 9 contributors for this article] (2023). Osteocyte-Like Cells Differentiated From Primary Osteoblasts in an Artificial Human Bone Tissue Model. JBMR Plus. ISSN 2473-4039. p. 1–10. doi: 10.1002/jbm4.10792. Full text in Research Archive
Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike Jeppesen; Ellingsen, Jan Eirik & Tiainen, Hanna (2023). Backscatter from therapeutic doses of ionizing irradiation does not impair cell migration on titanium implants in vitro. Clinical Oral Investigations. ISSN 1432-6981. doi: 10.1007/s00784-023-05128-6. Full text in Research Archive
Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike Jeppesen; Tiainen, Hanna & Ellingsen, Jan Eirik (2023). The dose-dependent impact of γ-radiation reinforced with backscatter from titanium on primary human osteoblasts. Biomaterial Investigations in Dentistry. 10(1). doi: 10.1080/26415275.2023.2209116. Full text in Research Archive
Yaddehi Gamage, Thilini Hansamali Gamage; Grabmayr, Herwig; Horvath, Ferdinand; Fahrner, Marc; Misceo, Doriana & Louch, William Edward [Show all 21 contributors for this article] (2023). A single amino acid deletion in the ER Ca2+ sensor STIM1 reverses the in vitro and in vivo effects of the Stormorken syndrome-causing R304W mutation. Science Signaling. ISSN 1945-0877. 16(771). doi: 10.1126/scisignal.add0509. Full text in Research Archive
Spoutil, Frantisek; Aranaz-Novaliches, Goretti; Prochazkova, Michaela; Wald, Tomas; Novosadova, Vendula & Kasparek, Petr [Show all 14 contributors for this article] (2023). Early evolution of enamel matrix proteins is reflected by pleiotropy of physiological functions. Scientific Reports. ISSN 2045-2322. 13(1). doi: 10.1038/s41598-023-28388-4. Full text in Research Archive
Agger, Anne Eriksson; Reseland, Janne Elin; Hjelkrem, Erik; Lian, Aina-Mari; Hals, Else Kristine Breivik & Zandi, Homan [Show all 7 contributors for this article] (2023). Are comorbidities associated with the cytokine/chemokine profile of persistent apical periodontitis? Clinical Oral Investigations. ISSN 1432-6981. 27, p. 5203–5215. doi: 10.1007/s00784-023-05139-3.
Yang, Yang; Geng, Tianxiang; Samara, Athina; Olstad, Ole Kristoffer; He, Jianying & Agger, Anne Eriksson [Show all 11 contributors for this article] (2023). Recombinant irisin enhances the extracellular matrix formation, remodeling potential, and differentiation of human periodontal ligament cells cultured in 3D. Journal of Periodontal Research. ISSN 0022-3484. 58(2), p. 336–349. doi: 10.1111/jre.13094. Show summary
Abstract Background Irisin is expressed in human periodontal ligament (hPDL), and its administration enhances growth, migration and matrix deposition in hPDL cells cultured in monolayers in vitro. Objectives To identify whether irisin affects the gene expression patterns directing the morphology, mechanical properties, extracellular matrix (ECM) formation, osteogenic activity and angiogenic potential in hPDL cell spheroids cultured in 3D. Materials and Methods Spheroids of primary human hPDL cells were generated in a rotational 3D culture system and treated with or without irisin. The gene expression patterns were evaluated by Affymetrix microarrays. The morphology of the spheroids was characterized using histological staining. Mechanical properties were quantified by nanoindentation. The osteogenic and angiogenic potential of spheroids were assessed through immunofluorescence staining for collagen type I, periostin fibronectin and von Willebrand factor (vWF), and mRNA expression of osteogenic markers. The secretion of multiple myokines was evaluated using Luminex immunoassays. Results Approximately 1000 genes were differentially expressed between control and irisin-treated groups by Affymetrix. Several genes related to ECM organization were differentially expressed, and multiple deubiquitinating enzymes were upregulated in the irisin-exposed samples analyzed. These represent cellular and molecular mechanisms indicative of a role for irisin in tissue remodeling. Irisin induced a rim-like structure on the outer region of the hPDL spheroids, ECM-related protein expression and the stiffness of the spheroids were enhanced by irisin. The expression of osteogenic and angiogenetic markers was increased by irisin. Conclusions Irisin altered the morphology in primary hPDL cell-derived spheroids, enhanced its ECM deposition, mechanical properties, differentiation and remodeling potential.
Pietryga, Krzysztof; Reczyńska-Kolman, Katarzyna; Reseland, Janne Elin; Haugen, Håvard Jostein; Larreta-Garde, Véronique & Pamula, Elzbieta (2023). Biphasic monolithic osteochondral scaffolds obtained by diffusion-limited enzymatic mineralization of gellan gum hydrogel. Biocybernetics and Biomedical Engineering (BBE). ISSN 0208-5216. doi: 10.1016/j.bbe.2022.12.009. Full text in Research Archive Show summary
Biphasic monolithic materials for the treatment of osteochondral defects were produced from polysaccharide hydrogel, gellan gum (GG). GG was enzymatically mineralized by alkaline phosphatase (ALP) in the presence of calcium glycerophosphate (CaGP). The desired distribution of the calcium phosphate (CaP) mineral phase was achieved by limiting the availability of CaGP to specific parts of the GG sample. Therefore, mineralization of GG was facilitated by the diffusion of CaGP, causing the formation of the CaP gradient. The distribution of CaP was analyzed along the cross section of the GG. The formation of a CaP gradient was mainly affected by the mineralization time and the ALP concentration. The formation of CaP was confirmed by Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy and mapping, as well as energy-dispersive X-ray spectroscopy (EDX) mapping of the interphase. The microstructure of mineralized and non-mineralized parts of the material was characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM) showing sub-micrometer CaP crystal formation, resulting in increased surface roughness. Compression tests and rheometric analyzes showed a 10-fold increase in stiffness of GG mineralized part. Concomitantly, micromechanical tests performed by AFM showed an increase of Young's modulus from 17.8 to more than 200 kPa. In vitro evaluation of biphasic scaffolds was performed in contact with osteoblast-like MG-63 cells. The mineralized parts of GG were preferentially colonized by the cells over the non-mineralized parts. The results showed that osteochondral scaffolds of the desired structure and properties can be made from GG using a diffusion-limited enzymatic mineralization method.
Hongji, Yan; De Deus, Gustavo; Kristoffersen, Ida Marie; Wiig, Elisabeth; Reseland, Janne Elin & Johnsen, Gaute Floer [Show all 8 contributors for this article] (2022). Regenerative Endodontics by Cell Homing: A Review of Recent Clinical trials. Journal of Endodontics. ISSN 0099-2399. 49(1), p. 4–17. doi: 10.1016/j.joen.2022.09.008. Full text in Research Archive
Krüger, Tormod Bjartveit; Syversen, Unni; Herlofson, Bente Brokstad; Lian, Aina-Mari & Reseland, Janne Elin (2022). Targeting a therapeutically relevant concentration of alendronate for in vitro studies on osteoblasts. Acta Odontologica Scandinavica. ISSN 0001-6357. 80(8), p. 619–625. doi: 10.1080/00016357.2022.2072522. Full text in Research Archive
Ribeiro, João P.; Domingues, Rui M.A.; Babo, Pedro S.; Parreiras Nogueira, Liebert; Reseland, Janne Elin & Reis, Rui L. [Show all 8 contributors for this article] (2022). Highly elastic and bioactive bone biomimetic scaffolds based on platelet lysate and biomineralized cellulose nanocrystals. Carbohydrate Polymers. ISSN 0144-8617. 292. doi: 10.1016/j.carbpol.2022.119638.
Schröder, Maria Elisabeth; Reseland, Janne Elin & Haugen, Håvard Jostein (2022). Osteoblasts in a Perfusion Flow Bioreactor—Tissue Engineered Constructs of TiO2 Scaffolds and Cells for Improved Clinical Performance. Cells. ISSN 2073-4409. 11(13). doi: 10.3390/cells11131995. Full text in Research Archive
D. Tien, Nguyen; Geng, Tianxiang; Heyward, Catherine Anne; Reseland, Janne Elin; Lyngstadaas, Ståle Petter & Blaker, Jonathan James [Show all 7 contributors for this article] (2022). Solution blow spinning of highly deacetylated chitosan nanofiber scaffolds for dermal wound healing. Materials Science and Engineering C: Materials for Biological Applications. ISSN 0928-4931. 137. doi: 10.1016/j.bioadv.2022.212871. Full text in Research Archive
Geng, Tianxiang; Heyward, Catherine Anne; Chen, Xi; Zheng, Mengxue; Yang, Yang & Reseland, Janne Elin (2022). Comprehensive Analysis Identifies Ameloblastin-Related Competitive Endogenous RNA as a Prognostic Biomarker for Testicular Germ Cell Tumour. Cancers. ISSN 2072-6694. 14(8). doi: 10.3390/cancers14081870.
Süslü, Safiyye; Høgestøl, Ingvild Kristine; Lian, Aina-Mari; Eriksen, Erik Fink & Reseland, Janne Elin (2022). Osteotropic proteins in bone marrow do not reflect abundance in bone and bone remodeling in obese females. Obesity Medicine. ISSN 2451-8476. 32, p. 1–8. doi: 10.1016/j.obmed.2022.100408.
Arnason, Niels Arni; Johannsson, Freyr; Landrö, Ragna; Hardarsson, Björn; Gudmundsson, Sveinn & Lian, Aina-Mari [Show all 9 contributors for this article] (2022). Protein Concentrations in Stored Pooled Platelet Concentrates Treated with Pathogen Inactivation by Amotosalen Plus Ultraviolet a Illumination. Pathogens. ISSN 2076-0817. 11(3). doi: 10.3390/pathogens11030350.
Syversen, Unni; Mosti, Mats Peder; Mynarek, Ida Maria; Vedal, Trude Seselie Jahr; Aasarød, Kristin Matre & Basso, Trude [Show all 11 contributors for this article] (2021). Evidence of impaired bone quality in men with type 1 diabetes: A cross-sectional study. Endocrine Connections. ISSN 2049-3614. 10(8), p. 955–964. doi: 10.1530/EC-21-0193. Full text in Research Archive Show summary
Objective Type 1 diabetes (T1D) is associated with substantial fracture risk. Bone mineral density (BMD) is, however, only modestly reduced, suggesting impaired bone microarchitecture and/or bone material properties. Yet, the skeletal abnormalities have not been uncovered. Men with T1D seem to experience a more pronounced bone loss than their female counterparts. Hence, we aimed to examine different aspects of bone quality in men with T1D. Design and Methods In this cross-sectional study, men with T1D and healthy male controls were enrolled. BMD (femoral neck, total hip, lumbar spine, whole body) and spine trabecular bone score (TBS) were measured by dual x-ray absorptiometry, and bone material strength index (BMSi) was measured by in vivo impact microindentation. HbA1c and bone turnover markers were analyzed. Results Altogether, 33 men with T1D (43 ± 12 years) and 28 healthy male controls (42 ± 12 years) were included. Subjects with T1D exhibited lower whole-body BMD than controls (P = 0.04). TBS and BMSi were attenuated in men with T1D vs controls (P = 0.016 and P = 0.004, respectively), and T1D subjects also had a lower bone turnover. The bone parameters did not differ between subjects with or without diabetic complications. Duration of disease correlated negatively with femoral neck BMD but not with TBS or BMSi. Conclusions This study revealed compromised bone material strength and microarchitecture in men with T1D. Moreover, our data confirm previous studies which found a modest decrease in BMD and low bone turnover in subjects with T1D. Accordingly, bone should be recognized as a target of diabetic complications.
Kruger, Tormod Bjartveit; Herlofson, Bente Brokstad; Lian, Aina-Mari; Syversen, Unni & Reseland, Janne Elin (2021). Alendronate and omeprazole in combination reduce angiogenic and growth signals from osteoblasts. Bone Reports. ISSN 2352-1872. 14:100750, p. 1–7. doi: 10.1016/j.bonr.2021.100750. Full text in Research Archive Show summary
Objective: Due to gastrointestinal side effects of oral bisphosphonates (BPs), proton pump inhibitors (PPIs) are often prescribed. PPIs may enhance the risk of osteonecrosis of the jaw, a rare side effect of BPs. Therefore, the objective of this study was to evaluate the effects of the oral BP alendronate (ALN) and the PPI omeprazole (OME) alone and in combination on primary human osteoblasts and gingival fibroblasts in vitro. Methods: Human gingival fibroblasts and normal human osteoblasts were incubated with either 5 μM of ALN or 1 μM of OME, or ALN + OME for 1, 3, 7 or 14 days. Effect on viability was evaluated by the lactate dehydrogenase activity in the medium and on proliferation by quantifying 3H-thymidin incorporation. Multianalyte profiling of proteins in cell culture media was performed using the Luminex 200TM system to assess the effect on selected bone markers and cytokines. Results: The proliferation of osteoblasts and fibroblasts was reduced upon exposure to ALN + OME. ALN induced an early, temporary rise in markers of inflammation, and OME and ALN + OME promoted a transient decline. An initial increase in IL-13 occurred after exposure to all three options, whereas ALN + OME promoted IL-8 release after 7 days. OME and ALN + OME promoted a transient reduction in vascular endothelial growth factor (VEGF) from osteoblasts, whereas ALN and ALN + OME induced a late rise in VEGF from fibroblasts. Osteoprotegerin release was enhanced by ALN and suppressed by OME and ALN + OME. Conclusions: ALN + OME seemed to exaggerate the negative effects of each drug alone on human osteoblasts and gingival fibroblasts. The anti-proliferative effects, modulation of inflammation and impairment of angiogenesis, may induce unfavorable conditions in periodontal tissue facilitating development of osteonecrosis.
Zhu, Hao; Haugen, Håvard Jostein; Perale, Giuseppe; Reseland, Janne Elin; Nogueira, Liebert Parreiras & Cantalapiedra, Antonio gonzalez [Show all 11 contributors for this article] (2021). Tailoring Resorption Rates and Osteogenic Response in Xeno-Hybrid Bone Grafts: The Effect of Added Gelatins. Engineering (Beijing). ISSN 2095-8099. 13, p. 197–208. doi: 10.1016/j.eng.2021.01.010. Full text in Research Archive
Yang, Yang; Pullisaar, Helen; Landin, Maria Augusta Dos S Silva; Heyward, Catherine Anne; Schröder, Maria & Geng, Tianxiang [Show all 8 contributors for this article] (2021). FNDC5/irisin is expressed and regulated differently in human periodontal ligament cells, dental pulp stem cells and osteoblasts. Archives of Oral Biology. ISSN 0003-9969. doi: 10.1016/j.archoralbio.2021.105061. Full text in Research Archive
Sukul, Mousumi; Sahariah, Priyanka; Lauzon, Hélène L.; Borges, João; Másson, Már & Mano, Joao F. [Show all 8 contributors for this article] (2021). In vitro biological response of human osteoblasts in 3D chitosan sponges with controlled degree of deacetylation and molecular weight. Carbohydrate Polymers. ISSN 0144-8617. 254. doi: 10.1016/j.carbpol.2020.117434. Full text in Research Archive Show summary
We have studied the effect of chitosan sponges, produced from chitosan batches with distinct degree of deacetylation (DDA) and molecular weight (Mw), on the adhesion, growth and differentiation of primary human osteoblasts with an aim to offer a suitable tool for guided bone regeneration. All the chitosan sponges revealed similar microstructure, irrespective of the DDA (58, 73, 82, 88, and 91 %) and Mw (749, 547, 263, 215, and 170 kDa, respectively). Cell spreading was higher on sponges having a higher DDA. Higher DDA induced a more pronounced increase in alkaline phosphatase activity, osteopontin (OPN), vascular endothelial growth factor-A (VEGF), interleukin-6 (IL-6), and reduction in monocyte chemoattractant protein-1 (MCP-1), sclerostin (SOST) and dickkopf related protein-1 as compared to lower DDA. Lower DDA induced the increased secretion of osteoprotegerin and SOST as compared to higher DDA. The combination of higher DDA and Mw induced an increased secretion of VEGF and IL-6, however reduced the secretion of OPN as compared to chitosan with similar DDA but with lower Mw. In summary, the variations in cellular responses to the different chitosan sponges indicate a potential for individual tailoring of desired responses in guided
Vetyskova, Veronika; Zouharova, Monika; Bednarova, Lucie; Vaněk, Ondřej; Sázelová, Petra & Kašička, Václav [Show all 14 contributors for this article] (2020). Characterization of AMBN I and II isoforms and study of their Ca2+ binding properties. International Journal of Molecular Sciences. ISSN 1661-6596. 21. doi: 10.3390/ijms21239293. Full text in Research Archive
Øyri, Hauk Furnes; Jensen, Janicke Liaaen; Barkvoll, Pål; Jonsdottir, Olga Hrønn; Reseland, Janne Elin & Bjørnland, Tore (2020). Incidence of alveolar osteitis after mandibular third molar surgery. Can inflammatory cytokines be identified locally? Acta Odontologica Scandinavica. ISSN 0001-6357. 79(3), p. 205–211. doi: 10.1080/00016357.2020.1817546. Full text in Research Archive
Haugen, Håvard Jostein; Marovic, Danijela; Par, Matej; Thieu, Minh Khai Le; Reseland, Janne Elin & Johnsen, Gaute Floer (2020). Bulk Fill Composites Have Similar Performance to Conventional Dental Composites. International Journal of Molecular Sciences. ISSN 1661-6596. 21(15). doi: 10.3390/ijms21145136. Full text in Research Archive Show summary
The aim of the study was to perform comprehensive characterization of two commonly used bulk fill composite materials (SDR Flow (SDR) and Filtek™ Bulk Fill Flowable Restorative (FBF) and one conventional composite material (Tetric EvoCeram; TEC). Eleven parameters were examined: flexural strength (FS), flexural modulus (FM), degree of conversion, depth of cure, polymerisation shrinkage (PS), filler particle morphology, filler mass fraction, Vickers hardness, surface roughness following simulated toothbrush abrasion, monomer elution, and cytotoxic reaction of human gingival fibroblasts, osteoblasts, and cancer cells. The degree of conversion and depth of cure were the highest for SDR, followed by FBF and TEC, but there was no difference in PS between them. FS was higher for bulk fill materials, while their FM and hardness were lower than those of TEC. Surface roughness decreased in the order TEC→SDR→FBF. Bisphenol A-glycidyl methacrylate (BisGMA) and urethane dimethacrylate were found in TEC and FBF eluates, while SDR released BisGMA and triethylene glycol dimethacrylate. Conditioned media accumulated for 24h from FBF and TEC were cytotoxic to primary human osteoblasts. Compared to the conventional composite, the tested bulk fill materials performed equally or better in most of the tests, except for their hardness, elastic modulus, and biocompatibility with osteoblasts.
Schröder, Maria; Riksen, Elisabeth Aurstad; He, Jianying; Skallerud, Bjørn Helge; Møller, Mona Elisabeth & Lian, Aina-Mari [Show all 8 contributors for this article] (2020). Vitamin K2 modulates vitamin D induced mechanical properties of human 3D bone spheroids in vitro. JBMR Plus. ISSN 2473-4039. 4(9). doi: 10.1002/jbm4.10394. Full text in Research Archive
Rahmati, Maryam; Frank, Matthias Johannes; Walter, Martin Sebastian; Monjo Cabrer, Marta; Satué, María & Reseland, Janne Elin [Show all 8 contributors for this article] (2020). Osteoimmunomodulatory effects of enamel matrix derivate and strontium coating layers: A short- and long-term in vivo study. ACS Applied Bio Materials (AABM). ISSN 2576-6422. 3, p. 5169–5181. doi: 10.1021/acsabm.0c00608. Full text in Research Archive Show summary
Over the past few years, surface modification of implant surface has gained substantial attention as a promising solution to avoid the failure of biomaterials after implantation. Although researchers suggest several strategies for surface functionalization of titanium based implants, only few studies have compared the osteoimmunomodulatory effects of ionic nanostructure and biofunctionalization in the same biological model. Enamel matrix derivate (EMD) and strontium are both known for their positive influences on bone cell responses. In this study, we functionalized the titanium-zirconium implant surface with EMD and strontium using an electrochemical cathodic polarization method. Afterwards, we evaluated the osteoimmunomodulatory effects of EMD or strontium coated titanium zirconium implants in the tibia of eight Grey Bastard Chinchillas rabbits. We performed 2&3D micro-CT, wound fluid, histologic, and histomorphometric analyses on bone tissues after 4- and 8-weeks implantation. Although the results could indicate some differences between groups regarding the bone quality, there was no difference in bone amount or volume. EMD stimulated higher ALP activity and lower cytotoxicity in wound fluid, as well as a lower expression of inflammatory markers after 8 weeks indicating its osteoimmunomodulatory effects after implantation. Overall, the results suggested that ionic nanostructure modification and biofunctionalization might be useful in regulating the immune responses to implants.
Rahmati, Maryam; Silva, Eduardo A.; Reseland, Janne Elin; Heyward, Catherine Anne & Haugen, Håvard Jostein (2020). Biological responses to physicochemical properties of biomaterial surface. Chemical Society Reviews. ISSN 0306-0012. 49(15), p. 5178–5224. doi: 10.1039/d0cs00103a. Full text in Research Archive Show summary
Biomedical scientists use chemistry-driven processes found in nature as an inspiration to design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue substitutes. While substantial consideration is devoted to the design and validation of biomaterials, the nature of their interactions with the surrounding biological microenvironment is commonly neglected. This gap of knowledge could be owing to our poor understanding of biochemical signaling pathways, lack of reliable techniques for designing biomaterials with optimal physicochemical properties, and/or poor stability of biomaterial properties after implantation. The success of host responses to biomaterials, known as biocompatibility, depends on chemical principles as the root of both cell signaling pathways in the body and how the biomaterial surface is designed. Most of the current review papers have discussed chemical engineering and biological principles of designing biomaterials as separate topics, which has resulted in neglecting the main role of chemistry in this field. In this review, we discuss biocompatibility in the context of chemistry, what it is and how to assess it, while describing contributions from both biochemical cues and biomaterials as well as the means of harmonizing them. We address both biochemical signal-transduction pathways and engineering principles of designing a biomaterial with an emphasis on its surface physicochemistry. As we aim to show the role of chemistry in the crosstalk between the surface physicochemical properties and body responses, we concisely highlight the main biochemical signal-transduction pathways involved in the biocompatibility complex. Finally, we discuss the progress and challenges associated with the current strategies used for improving the chemical and physical interactions between cells and biomaterial surface.
Brunetti, Giacomina; Storlino, Giuseppina; Oranger, Angela; Colaianni, Graziana; Faienza, Maria F & Ingravallo, Giuseppe [Show all 14 contributors for this article] (2020). LIGHT/TNFSF14 regulates estrogen deficiency‐induced bone loss. . Journal of Pathology. ISSN 0022-3417. 250, p. 440–451. doi: 10.1002/path.5385.
Ulmner, Mattias; Sugars, Rachael; Naimi-Akbar, Aron; Suslu, Safiyye; Reseland, Janne Elin & Kruger-Weiner, Carina [Show all 7 contributors for this article] (2020). Synovial tissue cytokine profile in disc displacement of the temporomandibular joint. Journal of Oral Rehabilitation. ISSN 0305-182X. 47(10), p. 1202–1211. doi: 10.1111/joor.13051. Full text in Research Archive
Rahmati, Maryam; Lyngstadaas, Ståle Petter; Reseland, Janne Elin; Andersbakken, Ingrid; Haugland, Heidi Straume & López-peña, Mónica [Show all 9 contributors for this article] (2020). Coating doxycycline on titanium-based implants: two in vivo studies. Bioactive Materials. ISSN 2452-199X. 5(4), p. 787–797. doi: 10.1016/j.bioactmat.2020.05.007. Full text in Research Archive Show summary
Regardless of the substantial progress in designing titanium-based dental implants and aseptic techniques, infection remains as the most common complication after implantation surgeries. Although, having a weakened immune system or systematic diseases is not seen as contraindicated for dental implants anymore, controlling the immune system is required to avoid surgical site infections after implantation. These patients have to control the surgical site infections by taking a high daily dose of oral antibiotics after dental implantation. The antibiotics oral administration has many side effects such as gastrointestinal symptoms, skin rashes and thrush. Coating antibiotics on the biomaterials surface could be a promising solution to reduce these disadvantages through locally releasing antibiotics in a controlled manner. The aim of this study was to investigate the effects of doxycycline coating layer on titanium-zirconium alloy surfaces in vitro and in vivo. In our previous studies, we demonstrated the chemical presence of doxycycline layer in vitro. In this study, we examined its physical presence using field emission scanning electron microscope and confocal microscope. We also analyzed its controlled released manner using Nano-Drop UV Vis spectrometer. After in vitro characterization of the coating layer, we evaluated its effects on the implant osseointegration in dogs and rabbits. The histological and histomorphometrical results exhibited no significant difference between doxycycline coated and uncoated groups regarding the implants osseointegration and biocompatibility for dental applications. Therefore, coating a doxycycline layer on TiZr implants could be favorable for reducing or removing the antibiotics oral administration after the implantation surgery.
Chahal, Aman S; Schweikle, Manuel; Lian, Aina-Mari; Reseland, Janne Elin; Haugen, Håvard Jostein & Tiainen, Hanna (2020). Osteogenic potential of poly(ethylene glycol)-amorphous calcium phosphate composites on human mesenchymal stem cells. Journal of Tissue Engineering. ISSN 2041-7314. 11. doi: 10.1177/2041731420926840. Full text in Research Archive
Shabestari, Maziar; Ghadakchi Shabestari, Yashar; Landin, Maria Augusta Dos S Silva; Pepaj, Milaim; Cleland, Timothy & Reseland, Janne Elin [Show all 7 contributors for this article] (2020). Altered protein levels in bone marrow lesions of hip osteoarthritis: Analysis by proteomics and multiplex immunoassays. International Journal of Rheumatic Diseases. ISSN 1756-1841. 23(6), p. 788–799. doi: 10.1111/1756-185X.13843. Full text in Research Archive
Haugen, Håvard Jostein; Basu, Poulami; Sukul, Mousumi; Mano, Joao F. & Reseland, Janne Elin (2020). Injectable biomaterials for Dental Tissue Regeneration. International Journal of Molecular Sciences. ISSN 1661-6596. 21. doi: 10.3390/ijms21103442. Full text in Research Archive Show summary
Injectable biomaterials scaffolds play a pivotal role for dental tissue regeneration, as such materials are more applicable in the dental field, particularly when compared to pre-formed scaffolds. The defects in maxilla-oral area are normally small, confined and sometimes hard to access. This narrative review described different types of biomaterials for dental tissue regeneration, also discussing the potential use of nanofibres for dental tissues. Various studies suggest that the tissue engineering approaches involving the use of injectable biomaterials have the potential of restoring not only dental tissue function but also their biological purposes
Sukul, Mousumi; Cama, Giuseppe; Dubruel, Peter; Reseland, Janne Elin & Haugen, Håvard Jostein (2020). Methacrylation increase growth and differentiation of primary human osteoblasts for gelatin hydrogels . Emergent Materials. ISSN 2522-5731. 3, p. 559–566. doi: 10.1007/s42247-020-00101-5. Full text in Research Archive Show summary
The role of gelatin methacrylate hydrogels with varying degree of methacrylation (69% and 84%) was accessed with FTIR, NMR, microCT and subsequently exposure to human osteoblasts. The cells responded positively to the degree of methacrylation and showed attachment, growth and proliferated on both hydrogels. The cell reacted differently to the degree of methacrylation with higher proliferation on higher substitution; however, cell differentiation behavior was improved for less substitution. The secretion of late osteogenic markers (Osteoprotegerin (OPG), Osteopontin (OPN) and Osteocalcein (OCN)) and angiogenic factor Vascular endothelial growth factor (VEGF) was increased for gelatin methacrylate hydrogels with 69% degree of methacrylation and thus would be the better candidate for future bone regenerative applications amongst the three tested hydrogels
Pham, Thi Ngoc Maria Huong; Haugen, Håvard Jostein & Reseland, Janne Elin (2020). Fluoride Modification of Titanium Surfaces Enhance Complement Activation. Materials. ISSN 1996-1944. 13(3). doi: 10.3390/ma13030684. Full text in Research Archive Show summary
Immediately after dental implant insertion, blood will be in direct contact and interact with the implant surface and activates inflammatory responses and complement cascades within seconds. The aim of the present study was to determine the ability of fluoride-modified titanium surfaces to activate complement cascades using the human buffy coat as model. The buffy coats were exposed to hydrofluoric acid-modified surfaces for a short time and its responses were compared to controls. Identification and quantification of complement cascade biomarkers were conducted using ELISA kits and multianalyte profiling using Luminex. A lower level of C3 at 30 min and increased levels of C4, MIP-4, CRP, and pigment epithelium-derived factor at 360 min were found on modified surfaces as compared to controls. We found no significant differences in the levels of C3a, C5a, C Factor H, α2M, ApoA1, ApoC3, ApoE, Prealbumin, α1AT, and SAP in modified surfaces in the buffy coats. We conclude that titanium surfaces treated with hydrofluoric acid modify the levels of specific biomarkers related to the complement cascade and angiogenesis and, thus, tissue growth, remodeling and repair, as this may play a role in the enhanced clinical performance of fluoride-modified Ti dental implants.
Beheshti Maal, Mehrnaz; Ellingsen, Stig Aanerød; Reseland, Janne Elin & Verket, Anders (2020). Experimental implantoplasty outcomes correlate with fibroblast growth in vitro. BMC Oral Health. ISSN 1472-6831. 20. doi: 10.1186/s12903-020-1012-1. Full text in Research Archive
Yaddehi Gamage, Thilini Hansamali Gamage; Lengle, Emma; Gunnes, Gjermund; Pullisaar, Helen; Holmgren, Asbjørn & Reseland, Janne Elin [Show all 16 contributors for this article] (2019). STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone. Cell Calcium. ISSN 0143-4160. 85. doi: 10.1016/j.ceca.2019.102110.
Brunetti, Giacomina; Belisario, DC; Bortolotti, Sara; Storlino, Giuseppina; Colaianni, Graziana & Faienza, Maria F [Show all 22 contributors for this article] (2019). LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients. Journal of Bone and Mineral Research. ISSN 0884-0431. 35(4), p. 671–680. doi: 10.1002/jbmr.3942.
Pullisaar, Helen; Colaianni, Graziana; Lian, Aina-Mari; Vandevska-Radunovic, Vaska; Grano, Maria & Reseland, Janne Elin (2019). Irisin promotes growth, migration and matrix formation in human periodontal ligament cells. Archives of Oral Biology. ISSN 0003-9969. doi: 10.1016/j.archoralbio.2019.104635. Full text in Research Archive
Giannobile, William V; Berglundh, Tord; Al-Nawas, Bilal; Araujo, Mauricio; Bartold, P Mark & Bouchard, Philippe [Show all 18 contributors for this article] (2019). Biological factors involved in alveolar bone regeneration: Consensus report of Working Group 1 of the 15th European Workshop on Periodontology on Bone Regeneration. Journal of Clinical Periodontology. ISSN 0303-6979. 46(S21), p. 6–11. doi: 10.1111/jcpe.13130.
Printzell, Lisa; Reseland, Janne Elin; Edin, Nina Frederike J & Ellingsen, Jan Eirik (2019). Effects of ionizing irradiation and interface backscatter on human mesenchymal stem cells cultured on titanium surfaces. European Journal of Oral Sciences. ISSN 0909-8836. 127(6), p. 500–507. doi: 10.1111/eos.12654. Full text in Research Archive
Zhu, Hao; Xiongfa, Ji; Hanfeng, Guan; Liming, Zhao; Libo, Zhao & Changyu, Liu [Show all 12 contributors for this article] (2019). Tantalum Nanoparticles Reinforced Polyetheretherketone Shows Enhanced Bone Formation. Materials Science and Engineering C: Materials for Biological Applications. ISSN 0928-4931. 101, p. 232–242. doi: 10.1016/j.msec.2019.03.091. Full text in Research Archive Show summary
Polyetheretherketone (PEEK) has been used in orthopedic surgery for several decades. Numerous methods were invented to alter the property of PEEK. By adding nanoparticles, fibers, elastic modulus and strength of PEEK can be changed to meet certain demand. In this study, tantalum (Ta), a promising metal, was introduced to modify the properties of PEEK, in which PEEK was reinforced with different contents of tantalum nanoparticles (from 1%wt to 9%wt). Mechanical properties and biological functions (both in vitro and in vivo) were then investigated. The highest elastic modulus and compressive strength were observed in 3%Ta-PEEK. Cell experiments as cell adhesion, collagen secretion, biomineralization and osteogenesis related gene expression showed preferable results in 3%Ta-PEEK and 5%Ta-PEEK. Improved bone integration was shown in 3%Ta-PEEK and 5%Ta-PEEK in vivo. Above all, enhanced mechanical properties and promoted bone formation were proved for 3%Ta-PEEK and 5%Ta-PEEK compared to others groups both in vivo and in vitro, suggesting that the addition of tantalum nanoparticles modified the osseointegration ability of PEEK. This composite of tantalum and PEEK could have a clinical potential for orthopedic implants.
Mann, Vivek; Grimm, Daniela; Corydon, Thomas J.; Krüger, Marcus; Wehland, Markus & Riwaldt, Stefan [Show all 14 contributors for this article] (2019). Changes in human foetal osteoblasts exposed to the random positioning machine and bone construct tissue engineering. International Journal of Molecular Sciences. ISSN 1661-6596. 30(6). doi: 10.3390/ijms20061357. Full text in Research Archive
Pham, Thi Ngoc Maria Huong; Haugen, Håvard Jostein; Rinna, Alessandra; Ellingsen, Jan Eirik & Reseland, Janne Elin (2019). Hydrofluoric acid treatment of titanium surfaces enhance the proliferation of human gingival fibroblasts. Journal of Tissue Engineering. ISSN 2041-7314. 10. doi: 10.1177/2041731419828950. Full text in Research Archive Show summary
The attachment of implants rely on bone and soft tissue biocompatibility. The aim was to investigate the effect of fluoride modified metallic titanium (Ti) surfaces (Ti-F) on proliferation and differentiation of human gingival fibroblasts (HGF). HGF cells were exposed to hydrofluoric acid (HF) modified Ti coins (Ti-F) for 1, 3, 7, 14 and 21d, and untreated coins were used as controls. A 5-6 fold increase in the proliferation of HGF on Ti-F compared to Ti surfaces was observed. Enhanced gene expression of IL-6 and OPG was found at 7 d. Increased levels of sclerostin, IL- 6 and OPG in the media from HGF cultured on Ti-F coins were found compared to controls. Our results confirm that HF modified surface may indirectly enhance the firm attachment of implant surface to junction epithelium, soft tissue epithelium, which would give protection for underlying osseous structures making osseointegration of the dental implant possible.
Stakkestad, Øystein; Heyward, Catherine Anne; Lyngstadaas, Ståle Petter; Medin, Tirill; Vondrasek, Jiri & Lian, Aina-Mari [Show all 8 contributors for this article] (2018). An ameloblastin C-terminus variant is present in human adipose tissue. Heliyon. ISSN 2405-8440. 4(12). doi: 10.1016/j.heliyon.2018.e01075. Full text in Research Archive
Shabestari, Maziar; Kise, Nina Jullum; Landin, Maria Augusta Dos S Silva; Sessing, Sølve; Hellund, Johan Castberg & Reseland, Janne Elin [Show all 8 contributors for this article] (2018). Enhanced angiogenesis and increased bone turnover characterize bone marrow lesions in osteoarthritis at the base of the thumb. Bone and Joint Research. ISSN 2046-3758. 7(6), p. 406–413. doi: 10.1302/2046-3758.76.BJR-2017-0083.R3. Full text in Research Archive
Colaianni, Graziana; Lippo, Luciana; Sanesi, Lorenzo; Brunetti, Giacomina; Celi, Monica & Cirulli, Nunzio [Show all 13 contributors for this article] (2018). Deletion of the Transcription Factor PGC-1? in Mice Negatively Regulates Bone Mass. Calcified Tissue International. ISSN 0171-967X. doi: 10.1007/s00223-018-0459-4. Full text in Research Archive
Haugen, Sigrid; He, Jianying; Sundaresan, Alamelu; Stunes, Astrid Kamilla; Aasarød, Kristin Matre & Tiainen, Hanna [Show all 9 contributors for this article] (2018). Adiponectin reduces bone stiffness; verified in a 3D artificial human bone model in vitro. Frontiers in Endocrinology. ISSN 1664-2392. 9:236, p. 1–12. doi: 10.3389/fendo.2018.00236. Full text in Research Archive
Colaianni, Graziana; Lippo, Luciana; Pignataro, Paolo; Sanesi, Lorenzo; Severi, Ilenia & Brunetti, Giacomina [Show all 11 contributors for this article] (2017). Treatment with r-irisin prevents and recovers disuse-induced bone loss and muscle atrophy. Italian Journal of Anatomy and Embryology. ISSN 2038-5129. 122(1).
Colaianni, Graziana; Lippo, Luciana; Pignataro, Paolo; Sanesi, Lorenzo; Spiro, Giovanna & Severi, Ilenia [Show all 14 contributors for this article] (2017). Unloaded Mice Treated with the Myokine Irisin Are Protected from Bone Loss and Muscle Atrophy. Journal of Bone and Mineral Research. ISSN 0884-0431. 32, p. 76–76.
Brunetti, Giacomina; Lippo, Luciana; Storlino, Giuseppina; Gigante, Isabella; Colaianni, Graziana & Di Benedetto, Adriana [Show all 15 contributors for this article] (2017). LIGHT/TNFSF14 deficiency affects basal bone remodeling through the regulation of osteoprotegerin expression. Journal of Bone and Mineral Research. ISSN 0884-0431. 32, p. 273–274. doi: 10.1002/jbmr.3345.
Colaianni, Graziana; Mongelli, Teresa; Cuscito, Concetta; Pignataro, Paolo; Lippo, Luciana & Spiro, Giovanna [Show all 18 contributors for this article] (2017). Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice. Scientific Reports. ISSN 2045-2322. 7(1). doi: 10.1038/s41598-017-02557-8. Full text in Research Archive
Brunetti, Giacomina; Faienza, MF; Colaianni, Graziana; Gigante, Isabella; Oranger, Angela & Pignataro, Paolo [Show all 21 contributors for this article] (2017). Impairment of bone remodeling in LIGHT/TNFSF14-deficient mice. Journal of Bone and Mineral Research. ISSN 0884-0431. 33(4), p. 704–719. doi: 10.1002/jbmr.3345.
Hussain, Badra; Thieu, Minh Khai Le; Johnsen, Gaute Floer; Reseland, Janne Elin & Haugen, Håvard Jostein (2017). Can CAD/CAM resin blocks be considered as substitute for conventional resins? Dental Materials. ISSN 0109-5641. 33(12), p. 1362–1370. doi: 10.1016/j.dental.2017.09.003. Show summary
Objective Dentists are facing a myriad of new CAD/CAM product for dental filling therapies. Are the new materials any worthwhile using? Are they succeeding the standard filling materials? Here we compare for the first time the new resin-composite blocks (RCBs) with conventional materials (Filtek Z250 and Tetric EvoCeram). Methods The material were tested for residual monomer elution by HPLC, thermogravimetric analysis (TG) was used to determine the percentage of fillers by weight, hardness was evaluated by Vickers method, morphology of fillers and distribution in the matrix were examined by scanning electron microscopy (SEM), elemental analysis for elemental determination of the filler particles was performed by energy-dispersive X-ray spectroscopy (EDX) cytotoxicity using human gingival fibroblasts and an epithelial cell line. Results The RBC outperformed conventional composite regarding mechanical characteristics (hardness) and monomer eluation, but showed some worrisome results regarding cytotoxicity. Significance The cost benefit is not in favour of RBCs in comparison to conventional composites, as the cytotoxicity was found higher for RBCs.
Haugen, Sigrid; Aasarød, Kristin Matre; Stunes, Astrid Kamilla; Mosti, Mats Peder; Franzen, Tanya Jeanette & Vandevska-Radunovic, Vaska [Show all 8 contributors for this article] (2017). Adiponectin prevents orthodontic tooth movement in rats. Archives of Oral Biology. ISSN 0003-9969. 83, p. 304–311. doi: 10.1016/j.archoralbio.2017.08.009. Full text in Research Archive
Stakkestad, Øystein; Lyngstadaas, Ståle Petter; Thiede, Bernd; Vondrasesek, Jiri; Skålhegg, Bjørn Steen & Reseland, Janne Elin (2017). Phosphorylation Modulates Ameloblastin Self-assembly and Ca2+ Binding. Frontiers in Physiology. ISSN 1664-042X. 8. doi: 10.3389/fphys.2017.00531. Full text in Research Archive
Stakkestad, Øystein; Lyngstadaas, Ståle Petter; Vondrášek, Jiří; Gordeladze, Jan Oxholm & Reseland, Janne Elin (2017). Ameloblastin peptides modulates the osteogenic capacity of human mesenchymal stem cells. Frontiers in Physiology. ISSN 1664-042X. 8. doi: 10.3389/fphys.2017.00058. Full text in Research Archive
Johnsen, Gaute Floer; Thieu, Minh Khai Le; Hussain, Badra; Pamula, Elzbieta; Reseland, Janne Elin & Lyngstadaas, Ståle Petter [Show all 7 contributors for this article] (2017). Own brand label restorative materials - A false bargain? Journal of Dentistry. ISSN 0300-5712. 56, p. 84–98. doi: 10.1016/j.jdent.2016.11.004. Show summary
Objectives This study aims at evaluating and comparing mechanical, chemical, and cytotoxicological parameters of a commercial brand name composite material against two ‘own brand label' (OBL) composites. Methods Parameters included depth of cure, flexural strength, degree of conversion, polymerization shrinkage, filler particle morphology and elemental analyses, Vickers hardness, surface roughness parameters after abrasion, monomer elution, and cytotoxicity. Results The conventional composite outperformed the OBLS in terms of depth of cure (p < 0.001), degree of cure at the first and last time intervals (p < 0.001), hardness (p < 0.001), and post-abrasion roughness (p < 0.05). The polymerization volumetric shrinkage ranged from 2.86% to 4.13%, with the highest shrinkage seen among the OBLs. Both Monomer elution from the OBLs was statistically significantly higher (p<0.001). Statistically significantly higher cytotoxicity combined with altered morphology and loss of confluence was detected in the cells exposed to extracts from the OBLs. Conclusions The OBLs were in general outdone by the conventional composite. Clinical Significance: OBLs restorative materials have become pervasive in the dental market. Manufacturers often promise equal or better characteristics than existing brand-name composites, but at a lower price. Dentists are highly recommended to reconsider utilization of OBLs lacking sound scientific scrutiny, and our findings underscore this recommendation
Aasarød, Kristin Matre; Ramezanzadehkoldeh, Masoud; Shabestari, Maziar; Mosti, Mats Peder; Stunes, Astrid Kamilla & Reseland, Janne Elin [Show all 15 contributors for this article] (2016). Skeletal effects of a gastrin receptor antagonist in H+/K+ATPase beta subunit KO mice. Journal of Endocrinology. ISSN 0022-0795. 230(2), p. 251–262. doi: 10.1530/JOE-16-0017.
Wiig, Elisabeth; Reseland, Janne Elin; Østbye, Kjartan; Haugen, Håvard Jostein & Vøllestad, Leif Asbjørn (2016). Variation in Lateral Plate Quality in Threespine Stickleback from Fresh, Brackish and Marine Water: A Micro-Computed Tomography Study. PLOS ONE. ISSN 1932-6203. 11(10). doi: 10.1371/journal.pone.0164578.
Kruger, Tormod Bjartveit; Herlofson, Bente Brokstad; Landin, Maria Augusta Dos S Silva & Reseland, Janne Elin (2016). Alendronate alters osteoblast activities. Acta Odontologica Scandinavica. ISSN 0001-6357. 74(7), p. 550–557. doi: 10.1080/00016357.2016.1217041.
Shabestari, Maziar; Vik, Jarle; Reseland, Janne Elin & Eriksen, Erik Fink (2016). Bone marrow lesions in hip osteoarthritis are characterized by increased bone turnover and enhanced angiogenesis. Osteoarthritis and Cartilage. ISSN 1063-4584. 24(10), p. 1745–1752. doi: 10.1016/j.joca.2016.05.009.
Grimm, Daniela; Grosse, Jirka; Wehland, Markus; Mann, Vivek; Reseland, Janne Elin & Sundaresan, Alamelu [Show all 7 contributors for this article] (2016). The impact of microgravity on bone in humans. Bone. ISSN 8756-3282. 87, p. 44–56. doi: 10.1016/j.bone.2015.12.057.
Villa , Oscar; Wohlfahrt, Johan Caspar; Koldsland, Odd Carsten; Brookes, Steven J; Lyngstadaas, Ståle Petter & Aass, Anne Merete [Show all 7 contributors for this article] (2016). EMD in periodontal regenerative surgery modulates cytokine profiles: A randomised controlled clinical trial. Scientific Reports. ISSN 2045-2322. 6, p. 1–9. doi: 10.1038/srep23060. Full text in Research Archive
Aasarød, Kristin Matre; Stunes, Astrid Kamilla; Mosti, Mats Peder; Ramezanzadehkoldeh, Masoud; Viggaklev, Bjørn Ivar & Reseland, Janne Elin [Show all 9 contributors for this article] (2016). Effects of the histamine 1 receptor antagonist cetirizine on the osteoporotic phenotype in H+ /K+ ATPase beta subunit KO mice. Journal of Cellular Biochemistry. ISSN 0730-2312. 117(9), p. 2089–2096. doi: 10.1002/jcb.25514.
Aasarød, Kristin Matre; Mosti, Mats Peder; Stunes, Astrid Kamilla; Reseland, Janne Elin; Basso, Trude & Syversen, Unni [Show all 7 contributors for this article] (2016). Impaired skeletal health in patients with chronic atrophic gastritis. Scandinavian Journal of Gastroenterology. ISSN 0036-5521. 51(7), p. 774–781. doi: 10.3109/00365521.2016.1141317.
Olsen-Bergem, Heming; Kristoffersen, Anne Karin; Bjørnland, Tore; Reseland, Janne Elin & Aas, Jørn Arne (2016). Juvenile idiopathic arthritis and rheumatoid arthritis: Bacterial diversity in temporomandibular joint synovial fluid in comparison with immunological and clinical findings. International Journal of Oral & Maxillofacial Surgery. ISSN 0901-5027. 45(3), p. 318–322. doi: 10.1016/j.ijom.2015.08.986.
Olsen-Bergem, Heming; Bjørnland, Tore & Reseland, Janne Elin (2015). Temporomandibular joint pain is negatively correlated to TNF alpha and osteoprotegrin content in synovial fluid in patients with juvenile idiopathic arthritis. Endocrinology & Metabolic Syndrome. ISSN 2161-1017. doi: 10.4172/2161-1017.1000145.
Villa , Oscar; Wohlfahrt, Johan Caspar; Mdala, Ibrahimu; Petzold, Christiane; Reseland, Janne Elin & Snead, Malcolm L. [Show all 7 contributors for this article] (2015). Proline-rich peptide mimic effects of EMD in rat oral mucosal incisional wound healing. Journal of Periodontology. ISSN 0022-3492. 86(12), p. 1386–1395. doi: 10.1902/jop.2015.150207.
Colaianni, Graziana; Cuscito, Concetta; Mongelli, Teresa; Pignataro, Paolo; Buccoliero, Cinzia & Liu, Peng [Show all 20 contributors for this article] (2015). The myokine irisin increases cortical bone mass. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 112(39), p. 12157–12162. doi: 10.1073/pnas.1516622112.
Villa, Oscar ; Brookes, Steven J; Thiede, Bernd; Heijl, Lars; Lyngstadaas, Ståle Petter & Reseland, Janne Elin (2015). Subfractions of enamel matrix derivative differentially influence cytokine secretion from human oral fibroblasts. Journal of Tissue Engineering. ISSN 2041-7314. 6, p. 1–11. doi: 10.1177/2041731415575857. Full text in Research Archive Show summary
Enamel matrix derivative is used to promote periodontal regeneration during the corrective phase of the treatment of periodontal defects. Our main goal was to analyze the bioactivity of different molecular weight fractions of enamel matrix derivative. Enamel matrix derivative, a complex mixture of proteins, was separated into 13 fractions using size-exclusion chromatography and characterized by sodium dodecyl sulfate–polyacrylamide gel electrophoresis and liquid chromatography–electrospray ionization–tandem mass spectrometry. Human periodontal ligament fibroblasts were treated with either enamel matrix derivative or the different fractions. Proliferation and cytokine secretion to the cell culture medium were measured and compared to untreated cells. The liquid chromatography–electrospray ionization–tandem mass spectrometry analyses revealed that the most abundant peptides were amelogenin and leucine-rich amelogenin peptide related. The fractions containing proteins above 20 kDa induced an increase in vascular endothelial growth factor and interleukin-6 secretion, whereas lower molecular weight fractions enhanced proliferation and secretion of interleukin-8 and monocyte chemoattractant protein-1 and reduced interleukin-4 release. The various molecular components in the enamel matrix derivative formulation might contribute to reported effects on tissue regeneration through their influence on vascularization, the immune response, and chemotaxis.
Pullisaar, Helen; Verket, Anders; Szoke, Krisztina; Tiainen, Hanna; Haugen, Håvard Jostein & Brinchmann, Jan E. [Show all 8 contributors for this article] (2015). Alginate hydrogel enriched with enamel matrix derivative to target osteogenic cell differentiation in TiO2 scaffolds. Journal of Tissue Engineering. ISSN 2041-7314. 6. doi: 10.1177/2041731415575870. Full text in Research Archive

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Reseland, Janne Elin & Yang, Yang (2022). Expression and Regulation of FNDC5/irisin in Periodontium and Dental Pulp. Archives of Dentistry. ISSN 2689-6222. doi: 10.33696/dentistry.4.022.
Sikorski, Pawel; Van Helvoort, Antonius; Christiansen, Emil; Vorwald, Charlotte E; Gonzalez-Fernandez, Tomas & Reseland, Janne Elin [Show all 8 contributors for this article] (2022). Spheroid-based model system to study bone mineralization in 3D.
Zhu, Hao; Ji, Xiongfa; Guan, Hanfeng; Zhao, Liming; Zhao, Libo & Liu, Changyu [Show all 12 contributors for this article] (2021). Corrigendum to “Tantalum nanoparticles reinforced polyetheretherketone shows enhanced bone formation” [Mater. Sci. Eng. C 101 (2019) 232–242] (Materials Science & Engineering C (2019) 101 (232–242), (S0928493118321453), (10.1016/j.msec.2019.03.091)). Materials Science and Engineering C: Materials for Biological Applications. ISSN 0928-4931. 128. doi: 10.1016/j.msec.2021.112332.
Rahmati, Maryam; Johannes Frank, Matthias; Martin Walter, Sebastian; Cabrer Monjo, Marta; Satué, Maria & Reseland, Janne Elin [Show all 8 contributors for this article] (2021). Osteo-immune responses to the enamel matrix derivative coating layer on titanium-based implants .
Suslu, Safiyye; Høgestøl, Ingvild Kristine; Eriksen, Erik Fink & Reseland, Janne Elin (2020). Changes in protein profile in bone marrow extracts before and one year after gastric bypass surgery. Bone Reports. ISSN 2352-1872. 13. doi: 10.1016/j.bonr.2020.100368.
Haugen, Håvard Jostein & Reseland, Janne Elin (2018). In vivo performance of a highly porous titanium dioxide bone scaffold and its way to the medical device market.
Haugen, Håvard Jostein; Reseland, Janne Elin & Gomez-Florit, Manuel (2018). The effect of IDP coated biomaterial.
Sundaresan, Alamelu; Olamigoke, Loretta; Mansoor, Elvedina; Devakottai, Ria; Reseland, Janne Elin & Brungs, Sonja [Show all 12 contributors for this article] (2017). Alleviation of inflammation and stimulation of the immune response by Active Hexose Correlated Compound (AHCC) in stressful physiological environments.
Shabestari, Maziar; Vik, Jarle; Reseland, Janne Elin & Eriksen, Erik Fink (2017). Erratum to "Bone marrow lesions in hip osteoarthritis are characterized by increased bone turnover and enhanced angiogenesis" [Osteoarthritis Cartilage 24 (2016) 1745-1752]. Osteoarthritis and Cartilage. ISSN 1063-4584. 25(4). doi: 10.1016/j.joca.2016.12.004.
Syversen, Unni; Mynarek, Ida Maria; Iversen, Trude Seselie Jahr; Eriksen, Erik Fink; Reseland, Janne Elin & Basso, Trude [Show all 10 contributors for this article] (2017). Impaired bone quality, assessed by trabecular bone score and in vivo micro indentation, in men with type 1 diabetes mellitus.
Gomez-Florit, Manuel; Reseland, Janne Elin & Haugen, Håvard Jostein (2017). Synthetic intrinsically-disordered-peptides for bone tissue engineering. Show summary
DISCUSSION & CONCLUSIONS: Results show that synthetic IDPs are able to influence hOBs biomineralization. The earlier upregulation of osteogenic markers together with the decreased wound area induced by P2 indicate that it has potential to induce bone regeneration. Bone related proteins, cytokines and chemokines released to culture media are already being analysed to confirm these results. IDPs might be a reliable option to develop new biomaterials and tissue engineering strategies
Haugen, Håvard Jostein; Johnsen, Gaute Floer; Reseland, Janne Elin; Hussain, Badra & Thieu, Minh Khai Le (2017). Can CAD/CAM Resin Blocks be Considered as a Substitute to Conventional Resins?
Aune, Guro; Lian, Aina-Mari; Tingulstad, Solveig; Torp, Sverre Helge; Forsmo, Siri & Reseland, Janne Elin [Show all 7 contributors for this article] (2015). Increased circulating hepatocyte growth factor (HGF): a marker of epithelial ovarian cancer and an indicator of poor prognosis.
Reseland, Janne Elin (2015). ODs bidrag til Forskningstorget på Universitetsplassen 18 og 19 september . [Radio]. NRK Østlandssendingen.
Reseland, Janne Elin (2015). Can signalling proteins of fat cells promote periodontal regeneration? . Show summary
Lunch & learing session Adipokines regulates the immune system, the inflammatory response as well as growth of various tissues. Obesity and the circulating level of adipokines are associated with periodontitis. Cells of craniofacial origin, like periodontal ligament cells (PDL) also express adipokines, and the expression and secretion of adipokines are regulated by e.g. Emdogain.
Aasarød, Kristin Matre; Ramezanzadehkoldeh, Masoud; Mosti, Mats Peder; Stunes, Astrid Kamilla; Reseland, Janne Elin & Skallerud, Bjørn Helge [Show all 8 contributors for this article] (2015). The osteoporotic phenotype in H+/K+ATPase beta subunit KO-mice is not influenced by a histamine 1 receptor antagonist.
Aasarød, Kristin Matre; Ramezanzadehkoldeh, Masoud; Shabestari, Maziar; Mosti, Mats Peder; Stunes, Astrid Kamilla & Reseland, Janne Elin [Show all 12 contributors for this article] (2015). Den osteoporotiske fenotypen til H+/K+ATPase beta-subunit KO mus bedres av en gastrinreseptorantagonist, men ikke av en histamin-1-reseptorantagonist.
Wiig, Elisabeth; Tiainen, Hanna; Lian, Aina-Mari; Mann, Vivek; Sundaresan, Alamelu & Haugen, Håvard Jostein [Show all 8 contributors for this article] (2015). Effect of microgravity on bone cells in bioinspired ceramic TiO2 scaffolds.
Chahal, Aman Singh; Schweikle, Manuel; Tiainen, Hanna; Koldsland, Odd Carsten; Reseland, Janne Elin & Haugen, Håvard Jostein (2015). Cell-responsive Biomimetic Extracellular Matrix Material for Bone and Dental Pulp Tissue Regeneration.
Longela, Simon Makusudi; Haugen, Håvard Jostein; Tiainen, Hanna; Lyngstadaas, Ståle Petter & Reseland, Janne Elin (2015). Biomolecular coating of nickel-titanium memory shape metals. European Cells and Materials. ISSN 1473-2262. 29.
Pham, Thi Ngoc Maria Huong; Rinna, Alessandra; Haugen, Håvard Jostein; Ellingsen, Jan Eirik & Reseland, Janne Elin (2015). Enhanced In Vitro HGF Proliferation and Differentiation on Surface Modified Hydrofluoric Acid treated TiO₂ .
Pham, Thi Ngoc Maria Huong; Rinna, Alessandra; Ellingsen, Jan Eirik; Haugen, Håvard Jostein & Reseland, Janne Elin (2015). Enhanced In Vitro HGF Proliferation and Differentiation on Surface Modified Hydrofluoric Acid treated TiO₂.
Villa , Oscar; Wohlfahrt, Johan Caspar; Mdala, Ibrahimu; Petzold, Christiane; Reseland, Janne Elin & Snead, Malcolm L. [Show all 7 contributors for this article] (2015). Proline-rich peptides accelerate oral mucosal wound healing.