Interference with bacterial communication and biofilm formation by synthetic thiophenones (completed)

Biofilm is the prefered mode of growth of bacteria in nature. Biofilm formation may be regulated via bacterial signaling. When organised in biofilms, bacteria show inceased tolerance towards antibacterial agents as well as the hosts immune system. Bacterial biofilms thus represent a challenge in medicine as well as in a range of other fields, including on- and off-shore industries. A common aim of the running projects is to synthesise and identify thiophenones with capacity to interfere with bacterial communication. Such interference will attenuate bacterial virulence and reduce biofilm formation, without the risk of antimicrobial resistance development.

The project has been granted by several grants from NFR (2008-2013)