Most recent publications

• Pedersen, AML; Skarstein, Kathrine; Çevik-Aras, H; Kullaa, AM; Laine, H & Jensen, Janicke Liaaen (2024). Sygdomme og tilstande der påvirker spytkirtlerne og deres funktion. Den norske tannlegeforenings tidende. ISSN 0029-2303.
• Huynh, Thuy-Tien Maria; Falk, Ragnhild Sørum; Hellebust, Taran Annette Paulsen; Dale, Einar; Astrup, Guro Lindviksmoen & Hjermstad, Marianne Jensen [Show all 12 contributors for this article] (2024). Chronic fatigue in long-term survivors of head and neck cancer treated with radiotherapy. Radiotherapy and Oncology. ISSN 0167-8140. 195. doi: 10.1016/j.radonc.2024.110231.
• Arroyo-Bote, Sebastiana; Bennasar-Verger, Catalina; Martínez-Jover, Andrés; Ferragut-Pina, Pablo; Riutot-Sbert, Pere & Lopez-Gonzalez, Angel Arturo [Show all 7 contributors for this article] (2024). Development of a three-dimensional printed model from a digital impression of a real patient for aesthetic dentistry undergraduate teaching. Journal of Dental Education. ISSN 0022-0337. doi: 10.1002/jdd.13552.
• Monsen, Ragnhild Elisabeth; Lerdal, Anners; Gay, Caryl; Nordgarden, Hilde & Herlofson, Bente Brokstad (2024). A comparison of the prevalence of dry mouth and other symptoms using two different versions of the Edmonton Symptom Assessment System on an inpatient palliative care unit. BMC Palliative Care. ISSN 1472-684X. 23(1). doi: 10.1186/s12904-024-01405-7. Full text in Research Archive
• Rogn, Åsmund; Jensen, Janicke Liaaen; Iversen, Per Ole & Singh, Preet Bano (2024). Post-COVID-19 patients suffer from chemosensory, trigeminal, and salivary dysfunctions. Scientific Reports. ISSN 2045-2322. 14(1). doi: 10.1038/s41598-024-53919-y.
• Ulmner, Mattias; Bjørnland, Tore; Rosén, Annika; Berge, Trond Inge; Olsen-Bergem, Heming & Lund, Bodil (2024). Evidence for minimally invasive treatment—A systematic review on surgical management of disc displacement. Journal of Oral Rehabilitation. ISSN 0305-182X. doi: 10.1111/joor.13661.
• Taylor, Katherine J.; Amdal, Cecilie Delphin; Bjordal, Kristin; Astrup, Guro Lindviksmoen; Herlofson, Bente Brokstad & Duprez, Fréderic [Show all 36 contributors for this article] (2024). Long-term health-related quality of life in head and neck cancer survivors: A large multinational study. International Journal of Cancer. ISSN 0020-7136. doi: 10.1002/ijc.34861.
• Kise, Yoshitaka; Møystad, Anne; Kuwada, Chaki; Ariji, Eiichiro & Bjørnland, Tore (2024). Does ultrasound elastography have a role as a diagnostic method for Sjögren’s syndrome in the salivary glands? A systematic review. Oral Radiology. ISSN 0911-6028. p. 1–13. doi: 10.1007/s11282-024-00740-y.
• Bergem, Anne Kristine; Thorvaldsen, Nina Øye; Häikiö, Kristin & Olsen-Bergem, Heming (2024). "Some missions can be quite emotionally painful." Paramedic´s experience exercising coercion during assignments—A qualitative study. PLOS ONE. ISSN 1932-6203. 19(1). doi: 10.1371/journal.pone.0290593. Full text in Research Archive
• Bjørk, Mai Britt; Bleka, Øyvind; Kvaal, Sigrid Ingeborg; Sakinis, Tomas; Tuvnes, Frode Alexander & Eggesbø, Heidi Beate [Show all 7 contributors for this article] (2023). MRI segmentation of tooth tissue in age prediction of sub-adults — a new method for combining data from the 1st, 2nd, and 3rd molars. International journal of legal medicine (Print). ISSN 0937-9827. p. 1–11. doi: 10.1007/s00414-023-03149-0. Full text in Research Archive
• Storås, Andrea; Fineide, Fredrik; Magnø, Morten Schjerven; Thiede, Bernd; Chen, Xiangjun & Strumke, Inga [Show all 11 contributors for this article] (2023). Using machine learning model explanations to identify proteins related to severity of meibomian gland dysfunction. Scientific Reports. ISSN 2045-2322. 13(1). doi: 10.1038/s41598-023-50342-7. Full text in Research Archive
• Huynh, Thuy-Tien Maria; Dale, Einar; Falk, Ragnhild Sørum; Hellebust, Taran Annette Paulsen; Astrup, Guro Lindviksmoen & Malinen, Eirik [Show all 12 contributors for this article] (2023). Radiation-induced long-term dysphagia in survivors of head and neck cancer and association with dose-volume parameters. Radiotherapy and Oncology. ISSN 0167-8140. 190. doi: 10.1016/j.radonc.2023.110044. Full text in Research Archive
• Lunde Steen, Ingrid; Olsen-Bergem, Heming; Tangen, Marte Kvittum & Espnes, Ketil Arne (2023). Håndtering av antikoagulantia ved tannbehandling. Norsk tannlegeforening Tidende.
• Kvittum Tangen, Marte; Olsen-Bergem, Heming; Lunde Steen, Ingrid & Espnes, Ketil Arne (2023). Håndtering av antikoagulantia i tannlegepraksis. Utposten. ISSN 0800-5680.
• Fineide, Fredrik; Tashbayev, Behzod; Elgstøen, Katja B. Prestø; Mørk Sandås, Elise; Rootwelt, Helge & Hynne, Håvard [Show all 12 contributors for this article] (2023). Tear and Saliva Metabolomics in Evaporative Dry Eye Disease in Females. Metabolites. ISSN 2218-1989. 13(11). doi: 10.3390/metabo13111125. Full text in Research Archive
• Frigaard, Julie Mari; Hynne, Håvard & Jensen, Janicke Liaaen (2023). Development and Proposal of a Novel Scoring System to Classify Dry Mouth Severity. Applied Sciences. ISSN 2076-3417. 13(21). doi: 10.3390/app132111758. Full text in Research Archive
• Cross, Tanya; Foss Haug, Kari Bente; Brusletto, Berit; Ommundsen, Stine Kamilla; Siebke, Anne-Marie & Aspelin, Trude [Show all 12 contributors for this article] (2023). Non-Coding RNA in Salivary Extracellular Vesicles: A New Frontier in Sjögren’s Syndrome Diagnostics? International Journal of Molecular Sciences. ISSN 1661-6596. 24(17). doi: 10.3390/ijms241713409. Full text in Research Archive
• Frigaard, Julie Mari; Jensen, Janicke Liaaen; Galtung, Hilde & Hiorth, Marianne (2023). Stability and cytotoxicity of biopolymer-coated liposomes for use in the oral cavity. International Journal of Pharmaceutics. ISSN 0378-5173. 645. doi: 10.1016/j.ijpharm.2023.123407. Full text in Research Archive
• Bjørk, Mai Britt; Kvaal, Sigrid Ingeborg; Bleka, Øyvind; Sakinis, Tomas; Tuvnes, Frode Alexander & Haugland, Mari-Ann [Show all 8 contributors for this article] (2023). Prediction of Age Older than 18 Years in Sub-adults by MRI Segmentation of 1st and 2nd Molars. International journal of legal medicine (Print). ISSN 0937-9827. 137(5), p. 1515–1526. doi: 10.1007/s00414-023-03055-5. Full text in Research Archive
• Taylor, Katherine J.; Amdal, Cecilie Delphin; Bjordal, Kristin; Astrup, Guro Lindviksmoen; Herlofson, Bente Brokstad & Duprez, Fréderic [Show all 34 contributors for this article] (2023). Serious Long-Term Effects of Head and Neck Cancer from the Survivors’ Point of View. Healthcare. ISSN 2227-9032. 11(6). doi: 10.3390/healthcare11060906. Full text in Research Archive
• Bjørk, Mai Britt; Kvaal, Sigrid Ingeborg; Bleka, Øyvind; Sakinis, Tomas; Tuvnes, Frode Alexander & Haugland, Mari-Ann [Show all 8 contributors for this article] (2023). Age prediction in sub-adults based on MRI segmentation of 3rd molar tissue volumes. International journal of legal medicine (Print). ISSN 0937-9827. 137(3), p. 753–763. doi: 10.1007/s00414-023-02977-4. Full text in Research Archive
• Dahl, Anne Fykerud; Bergem, Anne Kristine; Bjørnland, Tore & Olsen-Bergem, Heming (2023). Temporomandibular pain and quality of life assessment in adolescents in a Norwegian cohort. Clinical and Experimental Dental Research. ISSN 2057-4347. doi: 10.1002/cre2.733. Full text in Research Archive
• Frigaard, Julie Mari; Hynne, Håvard; Randsborg, Karoline; Mellin-Olsen, Tonje; Hofgaard, Anne Kristine & Young, Alix [Show all 10 contributors for this article] (2023). Exploring oral health indicators, oral health-related quality of life and nutritional aspects in 23 medicated patients from a short-term psychiatric ward. Frontiers in Public Health. ISSN 2296-2565. 11. doi: 10.3389/fpubh.2023.1083256. Full text in Research Archive
• Monsen, Ragnhild Elisabeth; Kristoffersen, Anne Karin; Gay, Caryl; Herlofson, Bente Brokstad; Fjeld, Katrine Gahre & Hove, Lene Hystad [Show all 10 contributors for this article] (2023). Identification and susceptibility testing of oral candidiasis in advanced cancer patients. BMC Oral Health. ISSN 1472-6831. 23(1). doi: 10.1186/s12903-023-02950-y. Full text in Research Archive
• Bjørnland, Tore & Mork-Knutsen, Peer Olaf (2023). Surgical Treatment of Temporomandibular Joint Derangement: 30-Year Follow-Up of Temporomandibular Joint Discectomy, a Case Report and Literature Review. Dental Clinics of North America. ISSN 0011-8532. 67(1), p. 13–25. doi: 10.1016/j.cden.2022.07.002.
• Riutord-Sbert, Pere; Gil, Pilar Tomas; Pereira, Thais Christina; Szupiany-Janeczek, Teresa; Barkvoll, Pål & Lopez-Gonzalez, Angel Arturo [Show all 7 contributors for this article] (2023). Application of the metaverse as a learning technique in the degree of dentistry. Medicina balear. ISSN 1579-5853. Full text in Research Archive
• Diep, Phoi Phoi; Rüegg, Corina Silvia; Dirdal, Marta Maria; Brinch, Lorentz; BØ, KRISTINE & Fosså, Kristian [Show all 17 contributors for this article] (2022). Graft-Versus-Host-Disease and Health-Related Quality of Life in Young Long-term Survivors of Cancer and Allogeneic Hematopoietic Stem Cell Transplantation. Journal of Adolescent and Young Adult Oncology. ISSN 2156-5333. 12(1), p. 66–75. doi: 10.1089/jayao.2021.0196.
• Fineide, Fredrik; Storås, Andrea; Chen, Xiangjun; Magnø, Morten Schjerven; Yazidi, Anis & Riegler, Michael [Show all 7 contributors for this article] (2022). Predicting an unstable tear film through artificial intelligence. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-25821-y. Full text in Research Archive Show summary

  Dry eye disease is one of the most common ophthalmological complaints and is defined by a loss of tear film homeostasis. Establishing a diagnosis can be time-consuming, resource demanding and unpleasant for the patient. In this pilot study, we retrospectively included clinical data from 431 patients with dry eye disease examined in the Norwegian Dry Eye Clinic to evaluate how artificial intelligence algorithms perform on clinical data related to dry eye disease. The data was processed and subjected to numerous machine learning classification algorithms with the aim to predict decreased tear film break-up time. Moreover, feature selection techniques (information gain and information gain ratio) were applied to determine which clinical factors contribute most to an unstable tear film. The applied machine learning algorithms outperformed baseline classifications performed with ZeroR according to included evaluation metrics. Clinical features such as ocular surface staining, meibomian gland expressibility and dropout, blink frequency, osmolarity, meibum quality and symptom score were recognized as important predictors for tear film instability. We identify and discuss potential limitations and pitfalls.

• Huynh, Thuy-Tien Maria; Aass, Hans Christian Dalsbotten; Falk, Ragnhild Sørum; Astrup, Guro Lindviksmoen; Helland, Åslaug & Bjøro, Trine [Show all 14 contributors for this article] (2022). Associations between patient-reported late effects and systemic cytokines in long-term survivors of head and neck cancer treated with radiotherapy. Journal of cancer survivorship. ISSN 1932-2259. doi: 10.1007/s11764-022-01273-1. Full text in Research Archive Show summary

  Purpose Head and neck cancer (HNC) treatment may lead to late effects and impaired health-related quality of life of survivors. Knowledge on long-term late effects after radiotherapy (RT) and potential underlying biological mechanisms is lacking. We assessed the prevalence of xerostomia, dysphagia, and chronic fatigue (CF) in HNC survivors ≥ 5 years post-RT, and examined associations between pro-inflammatory cytokines and late effects. Methods In a cross-sectional study, 263 HNC survivors treated between 2007 and 2013 were enrolled. They completed validated questionnaires assessing xerostomia and dysphagia (the EORTC QLQ-H&N35), and CF (the Fatigue Questionnaire), and underwent blood sampling and clinical examination. Pro-inflammatory cytokines were analyzed in 262 survivors and 100 healthy age- and gender-matched controls. Results Median time since treatment was 8.5 years. The proportions of survivors reporting xerostomia, dysphagia, and CF were 58%, 31%, and 33%, respectively, with a preponderance of females. We found no significant associations between IL-6, IL-8, IP-10, TARC, TNF, or ENA-78 and the three late effects. The odds of having elevated levels of IL-6 and IP-10 were significantly higher in the survivors compared to the controls. Conclusions More than one-third of long-term HNC survivors experienced xerostomia, dysphagia, and CF. Persistent inflammation, with elevated systemic cytokines, was not associated with these late effects, although HNC survivors had higher levels of some cytokines than the controls. Implications for Cancer Survivors This study provides new knowledge on late effects that can serve as grounds for informing patients with HNC about risk of late effects more than 5 years after RT.

• Tanem, Kristine Eidal; Stensvold, Einar; Wilberg, Petter; Skaare, Anne B; Brandal, Petter & Herlofson, Bente Brokstad (2022). Oral and dental late effects in long-term survivors of childhood embryonal brain tumors. Supportive Care in Cancer. ISSN 0941-4355. 30, p. 10233–10241. doi: 10.1007/s00520-022-07405-8. Full text in Research Archive
• Lein, Ingvild Årøen; Bjørnland, Tore & Loro, Lado Lako (2022). Retrospective Study of Orbital and Orbitozygomaticomaxillary Complex Factures Treated at Aalesund Hospital Between 2002 and 2017. Craniomaxillofacial Trauma & Reconstruction. ISSN 1943-3875. 16(4), p. 292–300. doi: 10.1177/19433875221135932. Show summary

  Study Design Retrospective study. Objective To evaluate patient demographics, surgical management, and complications of orbital and orbitozygomaticomaxillary complex (OZMC) fractures treated at a district hospital in Norway. Methods The medical records of patients with orbital fractures treated at Aalesund hospital between January 2002 and July 2017 were reviewed. Data on demographics, signs and symptoms, cause of injury, fracture type, associated fractures, surgical management, and complications were collected. Results A total of 36 patients were reviewed. Males predominated (1:4.1), and fractures occurred mostly in patients 40–59 years (mean 41.8 years). Interpersonal violence was the leading cause of injury, followed by falls. Alcohol was significantly associated with assault caused fractures (P = .001). Orbitozygomaticomaxillary fractures were the most frequent, followed by pure orbital fractures. Clinical findings included periorbital ecchymosis (72%), swelling (56%), sensory nerve dysfunction (53%), diplopia (22%), and restricted eye motility (22%). Commotio cerebri was observed in more than half of our sample and 47% had other facial bone fractures. Referral to tertiary hospitals was done in 19% of the cases. The main treatment done was open reduction and internal fixation (ORIF) (45%). Infection was diagnosed in 17% and managed with antibiotics. Conclusions The incidence of orbital and OZMC fractures in Moere and Romsdal county in western Norway was low, occurring mainly in males over 40 years. The mechanism of injury was predominantly interpersonal violence and falls. A high proportion of the sample had minor traumatic brain injury (mTBI).

• Lundtoft, Christian; Pucholt, Pascal; Martin, Myriam; Bianchi, Matteo; Lundström, Emeli & Eloranta, Maija-Leena [Show all 49 contributors for this article] (2022). Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases. Arthritis & Rheumatology. ISSN 2326-5191. 74(8), p. 1440–1450. doi: 10.1002/art.42122. Full text in Research Archive
• Khatri, Bhuwan; Tessneer, Kandice L.; Rasmussen, Astrid; Aghakhanian, Farhang; Reksten, Tove Ragna & Adler, Adam [Show all 66 contributors for this article] (2022). Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells. Nature Communications. ISSN 2041-1723. 13(1), p. 1–17. doi: 10.1038/s41467-022-30773-y. Full text in Research Archive
• Krüger, Tormod Bjartveit; Syversen, Unni; Herlofson, Bente Brokstad; Lian, Aina-Mari & Reseland, Janne Elin (2022). Targeting a therapeutically relevant concentration of alendronate for in vitro studies on osteoblasts. Acta Odontologica Scandinavica. ISSN 0001-6357. 80(8), p. 619–625. doi: 10.1080/00016357.2022.2072522. Full text in Research Archive
• Frigaard, Julie Mari; Jensen, Janicke Liaaen; Galtung, Hilde & Hiorth, Marianne (2022). The Potential of Chitosan in Nanomedicine: An Overview of the Cytotoxicity of Chitosan Based Nanoparticles. Frontiers in Pharmacology. ISSN 1663-9812. 13. doi: 10.3389/fphar.2022.880377. Full text in Research Archive
• Hynne, Håvard; Tashbayev, Behzod; Diep, My Tien; Sødal, Anne Thea Tveit; Badian, Reza & Chen, Xiangjun [Show all 10 contributors for this article] (2022). The relationship between ocular and oral dryness in a cohort from the 65-year-old population in Norway. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-13985-6. Full text in Research Archive Show summary

  In the present study, the relationship between dry eyes and dry mouth was explored in 150 65-year-old subjects randomly selected from the general population in Oslo, Norway. The number of drugs, including xerogenic drugs, and current and previous systemic diseases were recorded. Ocular parameters recorded were the McMonnies Dry Eye Questionnaire, the Ocular Surface Disease Index, the Schirmer I Test, tear film break-up time and ocular surface staining. The oral parameters were xerostomia frequency, Summated Xerostomia Inventory, Clinical Oral Dryness Score, and unstimulated and stimulated whole saliva. The participants with current or previous systemic diseases had significantly more ocular and oral symptoms and significantly more oral clinical findings than the participants without a history of disease. Moreover, correlation and factor analyses demonstrated an association between subjective ocular and oral parameters. A significant correlation between the total number of drugs and the presence of ocular and oral symptoms was also noted. When the participants were categorized based on their ocular symptoms, poorer values were found for the oral parameters among the participants more troubled with dry eyes. The results in the present study call for increased awareness and an interdisciplinary approach in matters related to dry eyes and dry mouth.

• Carrasco, Diego Gonzales; Riutord-Sbert, Pere; Rojas, Daniela Paz Vallejos; Norton, Daniel Alexander; Szupiany-Janeczek, Teresa & Perez, Jorge Domínguez [Show all 9 contributors for this article] (2022). Digitization with 3D haptic technology in dental training. Digitalización con tecnología háptica 3D en la formación dental. Medicina balear. ISSN 1579-5853. 37(3), p. 142–146. doi: 10.3306/AJHS.2022.37.03.142. Full text in Research Archive
• Hynne, Håvard; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Thiede, Bernd; Palm, Øyvind & Amdal, Cecilie Delphin [Show all 10 contributors for this article] (2022). Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren’s Syndrome Patients. International Journal of Molecular Sciences. ISSN 1661-6596. 23(7). doi: 10.3390/ijms23073714. Full text in Research Archive Show summary

  Patients with head and neck cancer (HNC) and patients with primary Sjögren’s syndrome (pSS) may exhibit similar symptoms of dry mouth and dry eyes, as a result of radiotherapy (RT) or a consequence of disease progression. To identify the proteins that may serve as promising disease biomarkers, we analysed saliva and tears from 29 radiated HNC patients and 21 healthy controls, and saliva from 14 pSS patients by mass spectrometry-based proteomics. The study revealed several upregulated, and in some instances overlapping, proteins in the two patient groups. Histone H1.4 and neutrophil collagenase were upregulated in whole saliva of both patient groups, while caspase-14, histone H4, and protein S100-A9 were upregulated in HNC saliva only. In HCN tear fluid, the most highly upregulated protein was mucin-like protein 1. These overexpressed proteins in saliva and tears play central roles in inflammation, host cell injury, activation of reactive oxygen species, and tissue repair. In conclusion, the similarities and differences in overexpressed proteins detected in saliva from HNC and pSS patients may contribute to the overall understanding of the different pathophysiological mechanisms inducing dry mouth. Thus, the recurring proteins identified could possibly serve as future promising biomarkers

• Tanem, Kristine Eidal; Wilberg, Petter; Diep, Phoi Phoi; Ruud, Ellen; Skaare, Anne B & Brinch, Lorentz [Show all 7 contributors for this article] (2022). Oral chronic GVHD after allogeneic stem cell transplantation without total body irradiation performed at a young age. Supportive Care in Cancer. ISSN 0941-4355. 30(5), p. 4121–4128. doi: 10.1007/s00520-022-06836-7. Full text in Research Archive
• Chen, Xiangjun; Badian, Reza; Hynne, Håvard; Tashbayev, Behzod; Hove, Lene Hystad & Jensen, Janicke Liaaen [Show all 7 contributors for this article] (2022). Morphology of Meibomian Glands in A 65‐Year‐Old Norwegian Population without Dry Eye Disease. Journal of Clinical Medicine. ISSN 2077-0383. 11(3). doi: 10.3390/jcm11030527. Full text in Research Archive Show summary

  Analyses of meibography may help in the diagnosis, prevention, and management of meibomian gland dysfunction (MGD). However, there is currently a paucity of data regarding meibography analyses in the young elderly populations in the Nordic countries. In the current study, meibography of the upper and lower eyelids of 117 65-year-old residents in Oslo, Norway, who did not fulfil the diagnosis of dry eye disease (DED) were analysed. Meibomian gland (MG) dropout and tarsal areas were measured semi-automatically using ImageJ software. The relationship between morphological features of the MGs and clinical dry eye tests was examined. The median percent MG dropout was 26.1% and 40.7% in the upper and lower eyelids, respectively. There was no significant difference between males and females. None of the MG morphological parameters demonstrated significant values in discriminating abnormal dry eye symptom loads or MGD diagnosis from the normal loads. We therefore concluded that moderate MG atrophy was common among the Norwegian population of 65-year-olds without DED and showed no sexual differences. Meibography alone cannot discriminate MGD from non-MGD; thus, both morphological and functional MG tests are necessary when screening for MGD.

• Hynne, Håvard; Mørk Sandås, Elise; Elgstøen, Katja B. Prestø; Rootwelt, Helge; Utheim, Tor Paaske & Galtung, Hilde [Show all 7 contributors for this article] (2022). Saliva Metabolomics in Dry Mouth Patients with Head and Neck Cancer or Sjögren’s Syndrome. Cells. ISSN 2073-4409. 11(3). doi: 10.3390/cells11030323. Full text in Research Archive Show summary

  The etiology of dry mouth conditions is multi-faceted. Patients radiated after head and neck cancer (HNC) and those with primary Sjögren’s syndrome (pSS) share many of the same symptoms despite different causes. With the aim of better understanding the pathophysiology and biochemical processes behind dry mouth with different etiologies, we investigated the metabolic profile of 10 HNC patients, 9 pSS patients and 10 healthy controls using high-performance liquid chromatography-high resolution mass spectrometry (HPLC-MS) metabolomics. Principal component analysis (PCA) revealed different metabolic profiles when comparing all subjects included in the study. Both patient groups showed higher ratios of several pyrimidine nucleotides and nucleosides when compared to controls. This finding may indicate that purinergic signaling plays a role in dry mouth conditions. Moreover, significantly increased levels of DL-3-aminoisobutyric acid were found in HNC patients when compared to controls, and a similar tendency was observed in the pSS patients. Furthermore, a dysregulation in amino acid metabolism was observed in both patient groups. In conclusion, metabolomics analysis showed separate metabolic profiles for HNC and pSS patients as compared to controls that could be useful in diagnostics and for elucidating the different pathophysiologies. The demonstrated dysregulation of pyrimidine nucleotides and levels of metabolites derived from amino acids in the patient groups should be studied further.

• Tanem, Kristine Eidal; Stensvold, Einar; Wilberg, Petter; Skaare, Anne B; Singh, Preet Bano & Brandal, Petter [Show all 7 contributors for this article] (2022). Taste and smell function in long-term survivors after childhood medulloblastoma/CNS-PNET. Supportive Care in Cancer. ISSN 0941-4355. 30, p. 6155–6162. doi: 10.1007/s00520-022-07048-9. Full text in Research Archive
• Singer, Susanne; Hammerlid, Eva; Tomaszewska, Iwona M; Amdal, Cecilie Delphin; Bjordal, Kristin & Herlofson, Bente Brokstad [Show all 31 contributors for this article] (2021). Methodological approach for determining the Minimal Important Difference and Minimal Important Change scores for the European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module (EORTC QLQ-HN43) exemplified by the Swallowing scale. Quality of Life Research. ISSN 0962-9343. doi: 10.1007/s11136-021-02939-6.

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• Ringstad, Ingrid Beate; Romskaug, Rita; Fjeld, Katrine Gahre; Hove, Lene Hystad; Roa, Leonor & Wyller, Torgeir Bruun [Show all 7 contributors for this article] (2024). Preliminary data from the COOP II-study – exploring oral and general health among older people in need of short-time acute care.
• Hynne, Håvard; Frigaard, Julie Mari & Jensen, Janicke Liaaen (2024). Dry mouth severity score .
• Rogn, Åsmund; Jensen, Janicke Liaaen; Iversen, Per Ole & Singh, Preet Bano (2024). Correction to: Post-COVID-19 patients suffer from chemosensory, trigeminal, and salivary dysfunctions (Scientific Reports, (2024), 14, 1, (3455), 10.1038/s41598-024-53919-y). Scientific Reports. ISSN 2045-2322. 14(1). doi: 10.1038/s41598-024-59915-6.
• Ringstad, Ingrid Beate; Borge, Hanne; Fromreide, Siren; Galtung, Hilde; Jensen, Janicke Cecilie Liaaen & Skarstein, Kathrine (2024). Undersøkelse av mRNA-uttrykksmønstre for MMP7, MMP9 og TIMP1 i små spyttkjertler hos pasienter med primær Sjögrens syndrom (pSS) ved bruk av RNAscope®.
• Ringstad, Ingrid Beate; Borge, Hanne; Fromreide, Siren; Galtung, Hilde; Jensen, Janicke Cecilie Liaaen & Skarstein, Kathrine (2024). Investigating MMP7, MMP9 and TIMP1 mRNA expression patterns in minor salivary glands from patients with primary Sjögren’s syndrome (pSS) using RNAscope® .
• Riksen, Elisabeth Aurstad (2024). KURS I SEDASJON MED LYSTGASS OG BENZODIAZEPINER.
• Rogn, Åsmund; Jensen, Janicke Cecilie Liaaen & Singh, Preet Bano (2023). Compromised chemosensory, trigeminal and salivary function in Long-COVID patients .
• Ringstad, Ingrid Beate; Romskaug, Rita; Fjeld, Katrine Gahre; Hove, Lene Hystad; Santervas, Leonor Roa & Wyller, Torgeir Bruun [Show all 7 contributors for this article] (2023). What happens to oral health when multiborbidity, polypharmacy and frailty comes along?
• Ringstad, Ingrid Beate; Romskaug, Rita; Fjeld, Katrine Gahre; Hove, Lene Hystad; Santervas, Leonor Roa & Wyller, Torgeir Bruun [Show all 7 contributors for this article] (2023). Oral Health in Times of Frailty and Polypharmacy.
• Ringstad, Ingrid Beate; Borge, Hanne; Fromreide, Siren; Galtung, Hilde; Skarstein, Kathrine & Jensen, Janicke Cecilie Liaaen (2023). Increased Expression of Salivary Gland Chemokines in Primary Sjögren’s Syndrome.
• Jensen, Janicke Liaaen (2023). The aging mouth.
• Lofthus, Elisabeth & Jensen, Janicke Liaaen (2023). Ny Sjøgrens-medisin: - Lovende! [Newspaper]. Dagbladet +.
• Rasmussen Steien, Tore & Jensen, Janicke Liaaen (2023). Munntørrhet skyldes nesten alltid legemidler. [Business/trade/industry journal]. Farmatid.no.
• Jensen, Janicke Liaaen & Bruun Wyller, Torgeir (2023). Den multimedisinerte pasienten.
• Herlofson, Bente Brokstad (2023). Kjevebenspatologi og benmodulerende behandling - Betydning for pasienter med myelomatose?
• Herlofson, Bente Brokstad (2023). Munnhelse og kreft - Fokus på pasienter med myelomatose.
• Herlofson, Bente Brokstad & Langeland, Øystein (2023). Autotransplantasjon av tenner - Nytt fra kirurgens ståsted?
• Herlofson, Bente Brokstad; Vang, Kjersti & Berstad, Johanna Elisabeth Rykke (2023). Oral fokussanering i forbindelse med strålebehandling for hode-/halskreft.
• Herlofson, Bente Brokstad; Tingvoll, Dag Petter Nilsen & Giltvedt, Karen Marie (2023). The Scandinavian ONJ Cohort Study, an 8-years research collaboration - Focus on the Norwegian study results.
• Herlofson, Bente Brokstad (2023). Kjevebenspatologi - Antiresorptiv behandling og MRONJ med fokus på pasienter med osteoporose.
• Bjørk, Mai Britt; Kvaal, Sigrid Ingeborg; Bleka, Øyvind; Haugland, Mari-Ann; Lauritzen, Peter Mæhre & Eggesbø, Heidi Beate (2023). Prediction of age older than 18 years in sub-adults by MRI-segmentation of 1st, 2nd and 3rd molars .
• Bjørk, Mai Britt; Kvaal, Sigrid Ingeborg; Bleka, Øyvind; Sakinis, Tomas; Tuvnes, Frode Alexander & Haugland, Mari-Ann [Show all 8 contributors for this article] (2023). Prediction of age older than 18 years by MRI-segmentation of 1st, 2nd, and 3rd molars.
• Frigaard, Julie Mari; Jensen, Janicke Liaaen & Hynne, Håvard (2023). Development of a novel scoring system to classify dry mouth severity.
• Eaton, Kenneth A. & Barkvoll, Pål (2023). Dirty Mouths Kill ! The need for interprofessional education. Nurse Education in Practice. ISSN 1471-5953. 70. doi: 10.1016/j.nepr.2023.103673.
• Singh, Preet Bano; Rogn, Åsmund & Jensen, Janicke Cecilie Liaaen (2023). Management of chemosensory, trigeminal and salivary dysfunction in Long-COVID patients .
• Riksen, Elisabeth Aurstad (2023). Kurs i sedasjon med lystgass og legemidler.
• Khatri, Bhuwan; Tessneer, Kandice L.; Rasmussen, Astrid; Aghakhanian, Farhang; Reksten, Tove Ragna & Adler, Adam [Show all 66 contributors for this article] (2023). Author Correction: Genome-wide association study identifies Sjögren’s risk loci with functional implications in immune and glandular cells (Nature Communications, (2022), 13, 1, (4287), 10.1038/s41467-022-30773-y). Nature Communications. ISSN 2041-1723. 14(1). doi: 10.1038/s41467-023-36369-4.
• Søland, Tine Merete; Wilberg, Petter; Pham, Maria & Solheim, Tore Torsteinson (2022). Lokalisert juvenil spongiotisk gingival hyperplasi: En relativt ny sykdomsenhet. Norsk tannlegeforening Tidende. doi: 10.56373/2022-9-5.
• Herlofson, Bente Brokstad (2022). Oral helse og kreft - Dagens er fremtidens utfordringer.
• Herlofson, Bente Brokstad (2022). MRONJ - collaboration projects - International, national and single center ONJ studies.
• Herlofson, Bente Brokstad & Westgaard, Kristine Løken (2022). The Oral Health Subproject - part of the Late toxicity and long-term quality of life study in head and neck cancer survivors .
• Herlofson, Bente Brokstad (2022). Tann-og munnhelseutfordringer - ansvar og økonomi .
• Herlofson, Bente Brokstad (2022). The Scandinavian ONJ Cohort Study - ONJ collaboration projects.
• Herlofson, Bente Brokstad (2022). Oral helse og kreft - Tverrfaglige utfordringer .
• Jensen, Janicke Liaaen (2022). MN102 Munn- og tannsykdommer .
• Jensen, Janicke Liaaen (2022). The aging mouth.
• Jensen, Janicke Liaaen (2022). Kommentar til: Munnhelse i sykehjem – en undersøkelse gjort i Akershus. NTFs Tidende. 132(4), p. 666–667.
• Khatri, Bhuwan; Tessneer, Kandice L.; Rasmussen, Astrid; Aghakhanian, Farhang; Reksten, Tove Ragna & Adler, Adam [Show all 66 contributors for this article] (2022). Erratum: Author Correction: Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells (Nature communications (2022) 13 1 (4287)). Nature Communications. ISSN 2041-1723. 13(1). doi: 10.1038/s41467-022-34311-8.
• Frigaard, Julie Mari; Hynne, Håvard; Randsborg, Karoline; Mellin-Olsen, Tonje; Young, Alix & Rykke, Morten [Show all 10 contributors for this article] (2022). Oral health indicators, oral health-related quality of life and nutritional aspects in medicated patients suffering from anxiety, psychosis, and/or depression. Frontiers in Public Health. ISSN 2296-2565.
• Frigaard, Julie Mari; Hynne, Håvard; Young, Alix; Hove, Lene Hystad; Rykke, Morten & Singh, Preet Bano [Show all 7 contributors for this article] (2022). Do medicated psychiatric patients differ from other dry mouth patients? .
• Jensen, Janicke Liaaen (2022). Tann- og munnhelsens betydning for eldres ernæring.
• Jensen, Janicke Liaaen (2022). Dry mouth and oral health-related quality of life in various conditions including EDs.
• Jensen, Janicke Liaaen (2022). Interprofessional collaboration on integrating oral and general health for the elderly in various care settings.
• Monsen, Ragnhild Elisabeth; Nordgarden, Hilde; Gay, Caryl; Lerdal, Anners & Herlofson, Bente Brokstad (2022). Munntørrhet - et manglende symptom i Edmonton Symptom Assessment System?
• Monsen, Ragnhild Elisabeth; Kristoffersen, Anne Karin; Gay, Caryl; Herlofson, Bente Brokstad; Fjeld, Katrine Gahre & Hove, Lene Hystad [Show all 10 contributors for this article] (2022). Orale soppinfeksjoner - mer enn Candida albicans: mikrobiologiske analyser av prøver fra alvorlig syke pasienter med kreft . Show summary

  Bakgrunn Pasienter med alvorlig kreftsykdom er utsatte for orale soppinfeksjoner, grunnet sykdommen, kreftbehandling og/eller svekket immunforsvar. Orale soppinfeksjon påvirker pasienters matlyst, ernæringstilstand og livskvalitet. Candida albicans er en vanlig soppart i munnhulen, men forekomst av non-albicans Candida-arter, og i kombinasjon med C. albicans, er økende. Artene har varierende toleranse for antimykotiske midler, det kan gi behandlingsutfordringer. Hensikten med studien var å identifisere og resistensteste Candida sopparter i munnhulen til alvorlig syke pasienter med kreft. Metode Sopprøver tatt under studien Oral Health in Advanced Cancer i perioden 2014 – 2016, ble analysert høsten 2020. Pasientprøvene ble re-dyrket ved Institutt for oral biologi, Universitetet i Oslo. Soppartene ble identifisert biokjemisk og ved DNA sekvensering, og resistenstestet for antimykotiske legemidler: fluconazole, amphotericin B, anidulafungin og nystatin. Resultat Vi analyserte totalt 56 isolater fra 45 pasienter og identifiserte syv Candida arter og en Saccharomyces. Til sammen hadde 36 pasienter oppvekst av én soppart, og 9 pasienter hadde 2 til 3 ulike sopparter i munnhulen. Av C. albicans artene var 39 av 40 følsomme for fluconazole. To Candida parapsilosis og en Candida tropicalis var resistent mot anidulafungin. En C. tropicalis var resistent mot anidulafungin. En Candida glabrata var resistent mot fluconazole. Konklusjon Studien viste at forskjellige Candida arter forekommer både i monoinfeksjoner og blandingsinfeksjoner. C. albicans var dominerende med høy følsomhet for antimykotiske midler. Blandingsinfeksjoner kan komplisere behandlingen og forårsake gjentagende infeksjoner. Mikrobiologiske prøver og analyser med identifisering og resistenstesting, bør være en del av utredningen hos pasienter med alvorlig og tilbakevendende orale soppinfeksjoner.

• Monsen, Ragnhild Elisabeth; Kristoffersen, Anne Karin; Gay, Caryl; Herlofson, Bente Brokstad; Fjeld, Katrine Gahre & Hove, Lene Hystad [Show all 10 contributors for this article] (2022). Oral candidiasis in advanced cancer – identification and susceptibility testing of detected Candida species. Show summary

  Introduction: Candida albicans is the most common fungal species in the oral cavity. Increased prevalence of non-C. albicans are detected, and co-infection with C. albicans may have implications for treatment, due to antifungal resistance. The aim of the study was to assess the diversity and susceptibility of oral yeasts in patients with advanced cancer. Methods: Clinical fungal isolates were sampled in 2014-2016 from 45 patients in a hospice unit. Totally 56 isolates were grown on chromID Candida plates, prepared for biochemical identification, and controlled with DNA sequencing. E-test was performed with the antifungal agents fluconazole, amphotericin B, anidulafungin and nystatin were tested. Results: A total of 56 isolates were identified. Candida species was dominated by C. albicans at 71%, followed by C. glabrata 9%, C. parapsilosis 5%, C. tropicalis 4%, C. krusei 2%, C. guilliermondii 2% and C. dubliniesis 2%. Nine patients had 2-3 different species. C. albicans strains were susceptible to fluconazole in 97.5%. One C. parapsilosis and one C. tropicalis strain were resistant to anidulafungin. One C. glabrata was resistant to fluconazole and another was just below the threshold for resistance. The sequencing confirmed the biochemical identification. Conclusion: C. albicans was the most prevalent species. Variation in susceptibility was observed in patients with mixed colonies. Combinations of Candida species and the lack of identification and susceptibility testing may lead to inadequate treatment.

• Monsen, Ragnhild Elisabeth; Kristoffersen, Anne Karin; Gay, Caryl; Herlofson, Bente Brokstad; Fjeld, Katrine Gahre & Hove, Lene Hystad [Show all 10 contributors for this article] (2022). Identification and susceptibility testing of oral candidiasis in advanced cancer patients – an important diagnostic tool. Show summary

  Background: Candida albicans is the most common fungal species detected in the oral cavity. Studies of oral fungal samples have shown an increased prevalence of non-C. albicans species in mixed infection with C. albicans. Non-C. albicans and C. albicans are associated with varying degrees of resistance to azole. This may have implications for treatment, due to acquired antifungal resistance. Aims: To assess the diversity and susceptibility of detected Candida species in the oral cavity in patients with advanced cancer. Methods: Clinical fungal isolates sampled in 2014-2016 from 45 patients in a hospice unit were analyzed. A total of 56 isolates were grown on chromID Candida plates. After phenotypic identification by colour of the colonies, one single colony of each species was re-cultivated and prepared for identification on a VITEK2® system. Susceptibility testing with E-test was performed on RPMI agar, and the antifungal agents fluconazole, amphotericin B, anidulafungin and nystatin were tested. Results: A total of 56 Candida isolates were identified. The diversity of Candida species was dominated by C. albicans at 89%, followed by C. glabrata 11%, C. parapsilosis 7%, C. tropicalis 4%, C. krusei 2%, C. guilliermondii 2% and C. dubliniesis 2%. Thirty-six patients had monoculture, and nine patients had 2-3 different species detected. Almost all C. albicans strains (97.5%) were susceptible to fluconazole. One C. parapsilosis and one C. tropicalis strain were resistant to anidulafungin. One C. glabrata was resistant to fluconazole and another was just below the threshold for resistance. Conclusion: C. albicans was the most prevalent Candida species in our sample. Variation in susceptibility was observed in patients with both C. albicans and C. glabrata. Combinations of Candida species and the lack of identification and susceptibility testing may lead to inadequate treatment and accelerate the development of resistance.

• Bjørk, Mai Britt; Kvaal, Sigrid Ingeborg; Bleka, Øyvind; Sakinis, Tomas; Tuvnes, Frode Alexander & Lauritzen, Peter Mæhre [Show all 8 contributors for this article] (2022). MRI segmentation of 3rd molar tooth tissue volumes to predict age older than 18 years in sub-adults.
• Hol, Caroline; Arvidsson, Linda Zamoline; Larheim, Tore Arne; Bjørnland, Tore & Mork-Knutsen, Peer Olaf (2022). Radiologically diagnosed temporomandibular joint osteoarthritis 10 and 30 years after diskectomy.
• Barkvoll, Pål (2021). På tide med tettere integrering mellom helseutdanningene. Dagens medisin. ISSN 1501-4290.
• Jensen, Janicke Liaaen; Barkvoll, Pål & Cetrelli, Patrik (2021). Én innbygger – to journaler. Dagens medisin. ISSN 1501-4290.
• Hynne, Håvard; Sandås, Elise Mørk; Elgstøen, Katja B. Prestø; Rootwelt, Helge; Galtung, Hilde Kanli & Utheim, Tor Paaske [Show all 7 contributors for this article] (2021). Metabolomics Identify Patterns Indicating Potential Biomarkers in Primary Sjögren’s Syndrome .
• Hynne, Håvard; Aqrawi, Lara A.; Chen, Xiangjun; Amdal, Cecilie Delphin; Reppe, Sjur & Aass, Hans Christian Dalsbotten [Show all 14 contributors for this article] (2021). Cytokine profiling, clinical oral and ocular manifestations post radiotherapy .
• Frigaard, Julie Mari (2021). Home PCR.
• Frigaard, Julie Mari (2021). Development of a new liposomal product for dry mouth relief.
• Herlofson, Bente Brokstad (2021). Munnhulekreft - Orale potensielt maligne tilstander, orale alarmsymptomer Pasienter på benmodulerende behandling.
• Herlofson, Bente Brokstad (2021). Pasienter på antiresorptiv behandling og kjeveosteonekrose.

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