Kristine Løken Westgaard

• Hynne, Håvard; Aqrawi, Lara A.; Jensen, Janicke Liaaen; Thiede, Bernd; Palm, Øyvind & Amdal, Cecilie Delphin [Show all 10 contributors for this article] (2022). Proteomic Profiling of Saliva and Tears in Radiated Head and Neck Cancer Patients as Compared to Primary Sjögren’s Syndrome Patients. International Journal of Molecular Sciences. ISSN 1661-6596. 23(7). doi: 10.3390/ijms23073714. Full text in Research Archive Show summary

  Patients with head and neck cancer (HNC) and patients with primary Sjögren’s syndrome (pSS) may exhibit similar symptoms of dry mouth and dry eyes, as a result of radiotherapy (RT) or a consequence of disease progression. To identify the proteins that may serve as promising disease biomarkers, we analysed saliva and tears from 29 radiated HNC patients and 21 healthy controls, and saliva from 14 pSS patients by mass spectrometry-based proteomics. The study revealed several upregulated, and in some instances overlapping, proteins in the two patient groups. Histone H1.4 and neutrophil collagenase were upregulated in whole saliva of both patient groups, while caspase-14, histone H4, and protein S100-A9 were upregulated in HNC saliva only. In HCN tear fluid, the most highly upregulated protein was mucin-like protein 1. These overexpressed proteins in saliva and tears play central roles in inflammation, host cell injury, activation of reactive oxygen species, and tissue repair. In conclusion, the similarities and differences in overexpressed proteins detected in saliva from HNC and pSS patients may contribute to the overall understanding of the different pathophysiological mechanisms inducing dry mouth. Thus, the recurring proteins identified could possibly serve as future promising biomarkers

• Chen, Xiangjun; Badian, Reza; Hynne, Håvard; Amdal, Cecilie Delphin; Herlofson, Bente Brokstad & Utheim, Øygunn Aass [Show all 10 contributors for this article] (2021). Alterations in meibomian glands in patients treated with intensity-modulated radiotherapy for head and neck cancer. Scientific Reports. ISSN 2045-2322. 11:22419, p. 1–7. doi: 10.1038/s41598-021-01844-9. Full text in Research Archive
• Westgaard, Kristine Løken; Hynne, Håvard; Amdal, Cecilie Delphin; Young, Alix; Singh, Preet Bano & Chen, Xiangjun [Show all 12 contributors for this article] (2021). Oral and ocular late effects in head and neck cancer patients treated with radiotherapy. Scientific Reports. ISSN 2045-2322. 11:4026, p. 1–11. doi: 10.1038/s41598-021-83635-w. Full text in Research Archive
• Aqrawi, Lara A.; Chen, Xiangjun; Hynne, Håvard; Amdal, Cecilie Delphin; Reppe, Sjur & Aass, Hans Christian Dalsbotten [Show all 14 contributors for this article] (2020). Cytokines Explored in Saliva and Tears from Radiated Cancer Patients Correlate with Clinical Manifestations, Influencing Important Immunoregulatory Cellular Pathways. Cells. ISSN 2073-4409. 9(9). doi: 10.3390/cells9092050. Full text in Research Archive
• Herlofson, Bente Brokstad; Løken, Kristine & Støre, Geir (2012). Oral complications of modern cancer treatment . Den norske tannlegeforenings tidende. ISSN 0029-2303. 122, p. 130–133. Show summary

  The current trend in modern advanced cancer treatment involves a more complex and aggressive approach, applying a spectrum of modalities, ranging from surgery and radiotherapy to new chemo- and immunotherapy. They are all responsible for various degrees of oral complications and side effects, representing a challenge to the dental team, both in prophylaxis, diagnosis and treatment of such compromised patients, aiming to improve their quality of life. This presentation brings a survey of the current cancer treatment regimens and their effect on oro-facial tissues.

• Herlofson, Bente Brokstad & Løken, Kristine (2006). Hvordan påvirkes munnhulen av kreftbehandling? Den norske tannlegeforenings tidende. ISSN 0029-2303. 116(7), p. 414–418.

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• Herlofson, Bente Brokstad & Westgaard, Kristine Løken (2022). The Oral Health Subproject - part of the Late toxicity and long-term quality of life study in head and neck cancer survivors .
• Hynne, Håvard; Aqrawi, Lara A.; Chen, Xiangjun; Amdal, Cecilie Delphin; Reppe, Sjur & Aass, Hans Christian Dalsbotten [Show all 14 contributors for this article] (2021). Cytokine profiling, clinical oral and ocular manifestations post radiotherapy .
• Jensen, Janicke Liaaen; Chen, Xiangjun; Hynne, Håvard; Westgaard, Kristine Løken; Hove, Lene Hystad & Young, Alix [Show all 14 contributors for this article] (2019). Sjögren’s versus irradiated head-neck cancer patients: oral and ocular investigations.
• Hynne, Håvard; Westgaard, Kristine Løken; Herlofson, Bente Brokstad; Amdal, Cecilie Delphin; Hove, Lene Hystad & Young, Alix [Show all 10 contributors for this article] (2019). Oral and Ocular Findings in Radiated Head-and Neck Cancer Patients.
• Herlofson, Bente Brokstad; Kjølle, Gry Karina; Westgaard, Kristine Løken; Løndalen, Ayca & Bruland, Øyvind (2018). Osteonecrosis of the jaw in a patient with bone metastatic prostate cancer after long-term bisphosphonate treatment with severe deterioration following radium-223. Clinical Genitourinary Cancer. ISSN 1558-7673. p. 1–4. doi: 10.1016/j.clgc.2018.05.003.

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