Trude Handal

• Stueland, Håvard; Ørstavik, Dag Solmund & Handal, Trude (2023). Treatment outcome of surgical and non-surgical endodontic retreatment of teeth with apical periodontitis. International Endodontic Journal. ISSN 0143-2885. 56(6), p. 686–696. doi: 10.1111/iej.13914.
• Døving, Mats; Handal, Trude & Galteland, Pål (2020). Bakterielle odontogene infeksjoner. Tidsskrift for Den norske legeforening. ISSN 0029-2001. doi: 10.4045/tidsskr.19.0778.
• Søraas, Arne Vasli Lund; Olsen, Ingar; Sundsfjord, Arnfinn; Handal, Trude; Bjørang, Ola & Jenum, Pål (2014). Extended-spectrum beta-lactamase-producing bacteria are not detected in supragingival plaque samples from human fecal carriers of ESBL-producing Enterobacteriaceae. Journal of Oral Microbiology. ISSN 2000-2297. 6. doi: 10.3402/jom.v6.24026. Full text in Research Archive
• Ehrmann, Elodie; Handal, Trude; Tamanai-Shacoori, Zohreh; Bonnaure-Mallet, MB & Fosse, Thierry (2014). High prevalence of β-lactam and macrolide resistance genes in human oral Capnocytophaga species. Journal of Antimicrobial Chemotherapy. ISSN 0305-7453. 69(2), p. 381–384. doi: 10.1093/jac/dkt350.
• Handal, Trude; Caugant, Dominique A; Olsen, Ingar & Sunde, Pia Titterud (2009). Bacterial diversity in persistent periapical lesions on root-filled teeth. Journal of Oral Microbiology. ISSN 2000-2297. 1, p. 1–7. doi: 10.3402/jom.v1iO.1946.
• Handal, Trude; Olsen, Ingar; Walker, Clay B & Caugant, Dominique A (2005). Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiology Letters. ISSN 0378-1097. 242(2), p. 319–324. Show summary

  Fifty-three beta-lactamase-producing strains of oral bacteria isolated from patients with refractory periodontitis in Norway and USA were screened for the presence of the bla(TEM), bla(SHV), bla(OXA), bla(ampC), bla(cfxA), and bla(cepA/cblA) genes by the polymerase chain reaction (PCR). The PCR products were characterized by direct sequencing of the amplified DNA. Thirty-four of the 53 enzyme-producing strains (64%) were positive in one of the PCR assays. All beta-lactamase-producing Prevotella and Capnocytophaga spp. were CfxA positive. TEM-type beta-lactamases were identified in one strain each of Escherichia coli and Neisseria sp., and one strain of Citrobacter freundii possessed an AmpC-type beta-lactamase. Screening for gene cassettes and genes known to be associated with integrons did not reveal the presence of integrons in these oral bacteria. Sequence analyses showed that most CfxA positive Prevotella and Capnocytophaga isolates from patients with refractory periodontitis harboured variants of the CfxA2 and CfxA3 enzyme. The present study also showed that many different genetic determinants of beta-lactamase production are found in bacteria isolated from refractory periodontitis, many of which remain to be characterized.

• Handal, Trude; Giraud-Morin, Chantal; Caugant, Dominique A; Madinier, Isabelle; Olsen, Ingar & Fosse, Thierry (2005). Chromosome- and plasmid-encoded beta-lactamases in Capnocytophaga spp. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804. 49(9), p. 3940–3943. doi: 10.1128/AAC.49.9.000-000.2005.
• Handal, Trude; Olsen, Ingar; Walker, Clay B & Caugant, Dominique A (2004). beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiology and Immunology. ISSN 0902-0055. 19, p. 303–308.
• Handal, Trude; Caugant, Dominique A & Olsen, Ingar (2003). Antibiotic resistance in bacteria isolated from subgingival plaque in a Norwegian population with refractory marginal periodontitis. Antimicrobial Agents and Chemotherapy. ISSN 0066-4804. 47(4), p. 1443–1446. Show summary

  The prevalence of beta-lactamase-producing bacteria in subgingival plaque from patients with refractory periodontitis in Norway was assessed by the chromogenic nitrocefin method. beta-Lactamase activity was detected in 68% of the patients. Enzyme-producing strains belonged predominantly to the genus Prevotella; others were staphylococci, enteric gram-negative rods, and Bacillus spp.

• Handal, Trude & Olsen, Ingar (2002). Antibakteriell resistens med vekt på betalaktamaser. Tandläkartidningen. ISSN 0039-6982. 94(1), p. 30–35.
• Handal, Trude & Olsen, Ingar (2002). Antibakteriell resistens med vekt på betalaktamaser. Den norske tannlegeforenings tidende. ISSN 0029-2303. 112(1), p. 20–24.
• Handal, Trude & Olsen, Ingar (2002). Bakteerien resistenssi ja beetalaktamaasit. Suomen hammaslaakarilehti. ISSN 0355-4090. IX(6), p. 282–286.
• Olsen, Ingar; Handal, Trude & Løkken, Per (2001). Bakteriedrepende virus som alternativ til antibiotika. Den norske tannlegeforenings tidende. ISSN 0029-2303. 111(1), p. 14–17.
• Olsen, Ingar; Handal, Trude & Løkken, Per (2001). Bakteriedrepende virus, stalinister og "superbugs". Tidsskrift for Den norske legeforening. ISSN 0029-2001. 121(27), p. 3197–3200.
• Handal, Trude & Olsen, Ingar (2000). Antimicrobial resistance with focus on beta-lactamases. European Journal of Oral Sciences. ISSN 0909-8836. 108, p. 163–174.

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• Handal, Trude (2022). Er du kalibrert?
• Handal, Trude & Sunde, Pia Titterud (2020). Rotresorpsjoner.
• Handal, Trude & Enersen, Morten (2017). Antibiotikabruk i primærhelsetjenesten Tannhelse, 1) Akutte odontogene infeksjoner; 2) Marginal periodontitt. Antibiotikabruk i Primærhelsetjenesten.
• Danielsen, Sigurd Haugan; Handal, Trude & Enersen, Morten (2015). Marginal periodontitt. Antibiotikabruk i Primærhelsetjenesten.
• Danielsen, Sigurd Haugan; Handal, Trude & Enersen, Morten (2015). Akutte odontogene infeksjoner. Antibiotikabruk i Primærhelsetjenesten.
• Handal, Trude; Ehrmann, E; Fosse, Thierry; Giraud-Morin, Chantal; Madinier, Isabelle & Bonnaure-Mallet, MB (2008). Prevalénce des genes de résistance aux Beta lactamines et aux macrolides chez Capnocytophaga selon les espèces et l´origine des souches.
• Handal, Trude (2008). Periodontitt og antibiotikaresistens.
• Sunde, Pia Titterud; Handal, Trude; Olsen, Ingar & Caugant, Dominique A (2007). Microbial diversity in therapy resistant periapical lesions.
• Handal, Trude (2006). Antibiotikaresistens - en økende utfordring i Norge.
• Handal, Trude; Giraud-Morin, C; Caugant, Dominique A; Madinier, I; Olsen, Ingar & Fosse, T (2005). Characterization of chromosome- and plasmid-encoded beta-lactamases in Capnocytophaga spp.
• Handal, Trude; Caugant, Dominique A & Olsen, Ingar (2001). B-lactamases and antimicrobial susceptibilities in periodontal bacteria isolated in Norway.
• Handal, Trude; Caugant, Dominique A & Olsen, Ingar (2000). B-Lactamases from subgingival bacteria isolated from refractory periodontitis in Norway.
• Handal, Trude; Caugant, Dominique A & Olsen, Ingar (2000). Beta-lactamases in refractory marginal periodontitis detected by nitrocefin test and isoelectric focusing.
• Handal, Trude; Olsen, Ingar & Caugant, Dominique A (2005). Antimicrobial resistance with focus on β-lactamases in subgingival bacteria from patients with refractory periodontitis. Unipub forlag. ISSN 82-91757-32-1.

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