Torben Hildebrand

Doctoral Research Fellow - Biomaterial Science

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Email torbehil@odont.uio.no

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Visiting address Geitmyrsveien 71 0455 Oslo

Postal address Postboks 1109 Blindern 0317 Oslo

Other affiliations Faculty of Dentistry (Student)

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Academic interests

Biomaterials, Contrast-enhanced CT, Micro- and Nano-CT

Higher education and employment history

Torben graduated with a Master of Science degree in Biomedical Engineering from Gottfried Wilhelm Leibniz University Hannover, Germany, in 2020.

Before joining Biomaterials Lab, he had done a research project at the University of Oslo with the Erasmus+ Programme.

His PhD project is focused on investigating contrast enhancement in dental research using micro-CT technology.

Boix Lemonche, Gerard; Hildebrand, Torben; Haugen, Håvard Jostein; Petrovski, Goran & Parreiras Nogueira, Liebert (2024). Contrast-enhanced Micro-CT 3D visualization of cell distribution in hydrated human cornea. Heliyon. ISSN 2405-8440. 10(3). doi: 10.1016/j.heliyon.2024.e25828. Full text in Research Archive
Hildebrand, Torben; Novak, Jan; Parreiras Nogueira, Liebert; Boccaccini, Aldo Roberto & Haugen, Håvard Jostein (2023). Durability assessment of hydrogel mountings for contrast-enhanced micro-CT. Micron. ISSN 0968-4328. 174. doi: 10.1016/j.micron.2023.103533. Full text in Research Archive Show summary
Micro-computed tomography (micro-CT) provides valuable data for studying soft tissue, though it is often affected by sample movement during scans and low contrast in X-ray absorption. This can result in lower image quality and geometric inaccuracies, collectively known as 'artefacts'. To mitigate these issues, samples can be embedded in hydrogels and enriched with heavy metals for contrast enhancement. However, the long-term durability of these enhancements remains largely unexplored. In this study, we examine the effects of two contrast enhancement agents – iodine and phosphotungstic acid (PTA) – and two hydrogels – agarose and Poloxamer 407 – over a 14-day period. We used Drosophila melanogaster as a test model for our investigation. Our findings reveal that PTA and agarose are highly durable, while iodine and poloxamer hydrogel exhibits higher leakage rates. These observations lay the foundation for estimating contrast stabilities in contrast-enhanced micro-CT with hydrogel embedding and serve to inform future research in this field.
Ma, Qianli; Rubenis, Kristaps; Sigurjonsson, Olafur E.; Hildebrand, Torben; Standal, Therese & Zemjane, Signe [Show all 9 contributors for this article] (2023). Eggshell-derived amorphous calcium phosphate: Synthesis, characterization and bio-functions as bone graft materials in novel 3D osteoblastic spheroids model. Smart Materials in Medicine. ISSN 2590-1834. 4, p. 522–537. doi: 10.1016/j.smaim.2023.04.001. Full text in Research Archive
Hildebrand, Torben; Parreiras Nogueira, Liebert; Sunde, Pia Titterud; Ørstavik, Dag Solmund; Glasmacher, Birgit & Haugen, Håvard Jostein (2021). Contrast-enhanced nano-CT reveals soft dental tissues and cellular layers. International Endodontic Journal. ISSN 0143-2885. 54(8), p. 1275–1288. doi: 10.1111/iej.13527.

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Haugen, Håvard Jostein; Parreiras Nogueira, Liebert & Hildebrand, Torben (2023). Novel techniques to visualise cellular tissues using X-ray imaging.

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Published May 31, 2022 11:41 AM - Last modified June 20, 2022 2:37 PM