Athina Samara

• Khalil, Asma; Samara, Athina; Campbell, Colin & Ladhani, Shamez N. (2024). Pregnant women and measles: we need to be vigilant during outbreaks. EClinicalMedicine. ISSN 2589-5370. 72. doi: 10.1016/j.eclinm.2024.102594.
• Khalil, A.; Samara, Athina; Coutinho, C.M. & Ladhani, S.N. (2024). Global efforts needed to address burden of preventable stillbirth. Ultrasound in Obstetrics and Gynecology. ISSN 0960-7692. 63(4), s. 441–445. doi: 10.1002/uog.27543.
• Phillips, Wiktor S.; Ramadan, Naify; Samara, Athina & Herlenius, Eric (2024). Protocol to dissect and dissociate the mouse brainstem for single-cell RNA-seq applications. STAR Protocols. ISSN 2666-1667. 5(1). doi: 10.1016/j.xpro.2024.102908.
• Reseland, Janne Elin; Heyward, Catherine Anne & Samara, Athina (2023). Revisiting ameloblastin; addressing the EMT-ECM axis above and beyond oral biology. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 11. doi: 10.3389/fcell.2023.1251540. Fulltekst i vitenarkiv Vis sammendrag

  Ameloblastin (AMBN) is best characterized for its role in dental enamel formation, regulating cell differentiation and mineralization, and cell matrix adhesion. However, AMBN has also been detected in mesenchymal stem cells in addition to bone, blood, and adipose tissue. Using immunofluorescence in a pilot scheme, we identified that AMBN is expressed in different parts of the gastrointestinal (GI) tract. AMBN mRNA and protein detection in several tissues along the length of the GI tract suggests a role for AMBN in the structure and tissue integrity of the extracellular matrix (ECM). Intracellular AMBN expression in subsets of cells indicates a potential alternative role in signaling processes. Of note, our previous functional AMBN promoter analyses had shown that it contains epithelial–mesenchymal transition (EMT) regulatory elements. ΑΜΒΝ is herein presented as a paradigm shift of the possible associations and the spatiotemporal regulation of the ECM regulating the EMT and vice versa, using the example of AMBN expression beyond oral biology.

• Spildrejorde, Mari; Samara, Athina; Sharma, Ankush; Leithaug, Magnus; Falck, Martin Bengt Alfred & Modafferi, Stefania [Vis alle 12 forfattere av denne artikkelen] (2023). Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamol. iScience. ISSN 2589-0042. 26:107755(10), s. 1–29. doi: 10.1016/j.isci.2023.107755. Fulltekst i vitenarkiv
• Mateu-Sanz, Miguel; Fuenteslópez, Carla V.; Uribe-Gomez, Juan; Haugen, Håvard Jostein; Pandit, Abhay & Ginebra, Maria-Pau [Vis alle 9 forfattere av denne artikkelen] (2023). Redefining biomaterial biocompatibility: challenges for artificial intelligence and text mining. Trends in Biotechnology. ISSN 0167-7799. doi: 10.1016/j.tibtech.2023.09.015. Fulltekst i vitenarkiv
• Geng, Tianxiang; Zheng, Mengxue; Wang, Yongfeng; Reseland, Janne Elin & Samara, Athina (2023). An artificial intelligence prediction model based on extracellular matrix proteins for the prognostic prediction and immunotherapeutic evaluation of ovarian serous adenocarcinoma. Frontiers in Molecular Biosciences. ISSN 2296-889X. 10. doi: 10.3389/fmolb.2023.1200354. Fulltekst i vitenarkiv
• Yang, Yang; Geng, Tianxiang; Samara, Athina; Olstad, Ole Kristoffer; He, Jianying & Agger, Anne Eriksson [Vis alle 11 forfattere av denne artikkelen] (2023). Recombinant irisin enhances the extracellular matrix formation, remodeling potential, and differentiation of human periodontal ligament cells cultured in 3D. Journal of Periodontal Research. ISSN 0022-3484. 58(2), s. 336–349. doi: 10.1111/jre.13094. Vis sammendrag

  Abstract Background Irisin is expressed in human periodontal ligament (hPDL), and its administration enhances growth, migration and matrix deposition in hPDL cells cultured in monolayers in vitro. Objectives To identify whether irisin affects the gene expression patterns directing the morphology, mechanical properties, extracellular matrix (ECM) formation, osteogenic activity and angiogenic potential in hPDL cell spheroids cultured in 3D. Materials and Methods Spheroids of primary human hPDL cells were generated in a rotational 3D culture system and treated with or without irisin. The gene expression patterns were evaluated by Affymetrix microarrays. The morphology of the spheroids was characterized using histological staining. Mechanical properties were quantified by nanoindentation. The osteogenic and angiogenic potential of spheroids were assessed through immunofluorescence staining for collagen type I, periostin fibronectin and von Willebrand factor (vWF), and mRNA expression of osteogenic markers. The secretion of multiple myokines was evaluated using Luminex immunoassays. Results Approximately 1000 genes were differentially expressed between control and irisin-treated groups by Affymetrix. Several genes related to ECM organization were differentially expressed, and multiple deubiquitinating enzymes were upregulated in the irisin-exposed samples analyzed. These represent cellular and molecular mechanisms indicative of a role for irisin in tissue remodeling. Irisin induced a rim-like structure on the outer region of the hPDL spheroids, ECM-related protein expression and the stiffness of the spheroids were enhanced by irisin. The expression of osteogenic and angiogenetic markers was increased by irisin. Conclusions Irisin altered the morphology in primary hPDL cell-derived spheroids, enhanced its ECM deposition, mechanical properties, differentiation and remodeling potential.

• Samara, Athina; Spildrejorde, Mari; Sharma, Ankush; Falck, Martin ; Leithaug, Magnus & Modafferi, Stefania [Vis alle 11 forfattere av denne artikkelen] (2022). A multi-omics approach to visualize early neuronal differentiation from hESCs in 4D. iScience. ISSN 2589-0042. 25(11). doi: 10.1016/j.isci.2022.105279. Fulltekst i vitenarkiv
• Samara, Athina & Belle, Branson (2021). Nanomaterials Upscaling Cell Production and Advancing Exosome-Based Stem Cell Therapies. Frontiers in Nanotechnology. ISSN 2673-3013. 3, s. 1–5. doi: 10.3389/fnano.2021.714824. Fulltekst i vitenarkiv
• Kondratskaya, Elena; Oleksandr, Ievglevskyi; Züchner, Mark; Samara, Athina; Glover, Joel & Boulland, Jean-Luc (2019). Locomotor central pattern generator excitability states and serotonin sensitivity after spontaneous recovery from a neonatal lumbar spinal cord injury. Brain Research. ISSN 0006-8993. 1708, s. 10–19. doi: 10.1016/j.brainres.2018.12.001.
• Bjørnstad, Sigrid; Samara, Athina; Erichsen, Aage; Paulsen, Ragnhild Elisabeth; Glover, Joel & Roald, Borghild (2016). Hampered lung maturation in methimazole-induced hypothyroidism in fetal chicken: morphological and molecular correlates to human fetal development. Neonatology. ISSN 1661-7800. 110(2), s. 83–92. doi: 10.1159/000444656.
• Paronis, Euthimios; Samara, Athina; Polyzos, A.; Spyropoulos, Constantine & Kostomitsopoulos, NG (2015). Maternal weight as an alternative determinant of the gestational day of Wistar rats housed in individually-ventilated cages. Laboratory Animals. ISSN 0023-6772. 49(3), s. 188–195. doi: 10.1177/0023677214562846.
• Lymperi, Stefania; Taraslia, Vasiliki; Tsatsoulis, Ioannis N.; Samara, Athina; Velentzas, Athanasios D. & Agrafioti, Anastasia [Vis alle 8 forfattere av denne artikkelen] (2015). Dental stem cell migration on pulp ceiling cavities filled with MTA, dentin chips, or Bio-Oss. BioMed Research International. ISSN 2314-6133. 2015:189872. doi: 10.1155/2015/189872.
• Samara, Athina; Galbiati, Mariarita; Luciani, Paola; Deledda, Cristiana; Messi, Elio & Peri, Alessandro [Vis alle 7 forfattere av denne artikkelen] (2014). Altered expression of 3-betahydroxysterol delta-24-reductase/selective Alzheimer's disease indicator-1 gene in Huntington's disease models. Journal of Endocrinological Investigation. ISSN 0391-4097. 37(8), s. 729–737. doi: 10.1007/s40618-014-0098-1.
• Stasinopoulou, Marianna; Mantziaras, George; Paronis, Euthimios; Balafas, Evangelos; Lelovas, Pavlos & Samara, Athina [Vis alle 7 forfattere av denne artikkelen] (2014). Use of real-time ultrasonography as an alternative method for early detection, confirmation and evaluation of rat pregnancy. Ultrasound in Medicine and Biology. ISSN 0301-5629. 40(6), s. 1372–1378. doi: 10.1016/j.ultrasmedbio.2013.11.016.
• Samara, Athina (2013). Single neurons needed for brain asymmetry studies. Frontiers in Genetics. ISSN 1664-8021. 4. doi: 10.3389/fgene.2013.00311.

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• Samara, Athina & Khalil, Asma (2023). Editorial: Unravelling human placental (patho-) physiology at the epigenetic and transcriptome level. Frontiers in Cell and Developmental Biology. ISSN 2296-634X. 11. doi: 10.3389/fcell.2023.1228803.
• Samara, Athina; Falck, Martin ; Spildrejorde, Mari; Leithaug, Magnus; Acharya, Ganesh & Lyle, Robert [Vis alle 7 forfattere av denne artikkelen] (2022). Robust neuronal differentiation of human embryonic stem cells for neurotoxicology. STAR Protocols. ISSN 2666-1667. 3(3). doi: 10.1016/j.xpro.2022.101533. Fulltekst i vitenarkiv

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