Daria Zaytseva-Zotova

• Rogala, Agnes; Zaytseva-Zotova, Daria; Oreja Remartinez, Enrique; Barrantes Bautista, Alejandro & Tiainen, Hanna (2024). Combining QCM-D with live-cell imaging reveals the impact of serum proteins on the dynamics of fibroblast adhesion on tannic acid-functionalised surfaces. Biomaterials Science. ISSN 2047-4830. 12, s. 3345– 3359. doi: 10.1039/d4bm00184b. Fulltekst i vitenarkiv
• Weber, Florian; Morais Dornelas Figueira, Louise; Hafiane, Nora; Zaytseva-Zotova, Daria; Barrantes Bautista, Alejandro & Petersen, Fernanda Cristina [Vis alle 7 forfattere av denne artikkelen] (2022). Can polyphenolic surface modifications prevent fungal colonization of titanium dental implants? Colloids and Surfaces B: Biointerfaces. ISSN 0927-7765. 219. doi: 10.1016/j.colsurfb.2022.112813. Fulltekst i vitenarkiv
• Kjesbu, Joachim Sebastian; Zaytseva-Zotova, Daria; Sämfors, Sanna; Gatenholm, Paul; Troedsson, Christofer & Thompson, Eric Malcolm [Vis alle 7 forfattere av denne artikkelen] (2022). Alginate and tunicate nanocellulose composite microbeads – Preparation, characterization and cell encapsulation. Carbohydrate Polymers. ISSN 0144-8617. 286. doi: 10.1016/j.carbpol.2022.119284. Fulltekst i vitenarkiv Vis sammendrag

  Alginate has been used for decades for cell encapsulation. Cellulose nanofibrils (CNF) from tunicates are desirable in biomedicine due to high molecular weight, purity, crystallinity, and sustainable production. We prepared microbeads of 400–600 μm of alginate and tunicate CNF. Greater size, dispersity and aspect ratio were observed in microbeads with higher fractions of CNF. CNF content in Ca-crosslinked alginate microbeads decreased stability upon saline exposure, whereas crosslinking with calcium (50 mM) and barium (1 mM) yielded stable microbeads. The Young's moduli of gel cylinders decreased when exchanging alginate with CNF, and slightly increased permeability to dextran was observed in microbeads containing CNF. Encapsulation of MC3T3 cells revealed high cell viability after encapsulation (83.6 ± 0.4%) in beads of alginate and CNF. NHDFs showed lower viability but optimizing mixing and production techniques of microbeads increased cell viability (from 66.2 ± 5.3% to 72.7 ± 7.5%).

• Akbarzadeh, Anita; Koernig, Andre; Kjesbu, Joachim Sebastian; Zaytseva-Zotova, Daria; Sletmoen, Marit & Strand, Berit Løkensgard (2021). High resolution imaging of soft alginate hydrogels by atomic force microscopy. Carbohydrate Polymers. ISSN 0144-8617. 276. doi: 10.1016/j.carbpol.2021.118804.
• Omtvedt, Line Aanerud; Kristiansen, Kåre Andre; Strand, Wenche Iren; Aachmann, Finn Lillelund; Strand, Berit Løkensgard & Zaytseva-Zotova, Daria (2021). Alginate hydrogels functionalized with β-cyclodextrin as a local paclitaxel delivery system. Journal of Biomedical Materials Research. Part A. ISSN 1549-3296. 109(12), s. 2625–2639. doi: 10.1002/jbm.a.37255. Fulltekst i vitenarkiv Vis sammendrag

  Modification of drug delivery materials with beta-cyclodextrins (β-CyD) is known to increase solubility of poorly water-soluble drugs, protect drugs from degradation and sustain release. In this study, we developed a hydrogel drug delivery system for local paclitaxel delivery using the natural polysaccharide alginate functionalized with β-CyD-moieties. Paclitaxel was chosen due to its ability to form inclusion complexes with cyclodextrins. The rheological and mechanical properties of the prepared hydro- gels were characterized, as well as in vitro release of the paclitaxel and in vitro activ- ity on PC-3 prostate cancer cells. Introduction of β-CyD-moieties into the hydrogel reduces the mechanical properties of the gels compared to nonmodified gels. How- ever, gelation kinetics were not markedly different. Furthermore, the β-CyD-modified alginate helped to reduce undesired crystallization of the paclitaxel in the gel and facilitated paclitaxel diffusion out of the gel network. Remarkably, the β-CyD grafted alginate showed increased capacity to complex paclitaxel compared to free HPβ- CyD. Release of both paclitaxel and degradation products were measured from the gels and were shown to have cytotoxic effects on the PC-3 cells. The results indicate that functionalized alginate with β-CyDs has potential as a material for drug delivery systems.

• Victoria, Moreno-Manzano; Zaytseva-Zotova, Daria; López-Mocholí, Eric; Briz-Redón, Álvaro; Strand, Berit Løkensgard & Serrano-Aroca, Angel (2020). Injectable Gel Form of a Decellularized Bladder Induces Adipose-Derived Stem Cell Differentiation into Smooth Muscle Cells In Vitro. International Journal of Molecular Sciences. ISSN 1661-6596. 21, s. 1–14. doi: 10.3390/ijms21228608. Fulltekst i vitenarkiv

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• Zaytseva-Zotova, Daria; Haslene-Hox, Hanne; Arlov, Øystein; Hoel, Andrea Draget; Mjelle, Robin & Strand, Wenche [Vis alle 13 forfattere av denne artikkelen] (2023). Alginate hydrogel characteristics regulate NHDF biology.
• Strand, Berit Løkensgard; Haslene-Hox, Hanne; Sætrom, Pål; Zaytseva-Zotova, Daria; Mjelle, Robin & Arlov, Øystein [Vis alle 12 forfattere av denne artikkelen] (2023). Alginate hydrogel characteristics regulate NHDF biology.
• Haslene-Hox, Hanne; Chahal, Aman Singh; Arlov, Øystein; Øynebråten, Ingrid Ryge; Zaytseva-Zotova, Daria & Vikenes, Anette [Vis alle 16 forfattere av denne artikkelen] (2023). Alginate hydrogel characteristics regulate fibroblast biology.
• Oreja Remartínez, Enrique; Tiainen, Hanna; Rogala, Agnieszka; Barrantes Bautista, Alejandro & Zaytseva-Zotova, Daria (2023). Tannic Acid/Polyamino acid Layer-by-Layer coating and their interaction with human cells.
• Rogala, Agnieszka; Zaytseva-Zotova, Daria; Barrantes Bautista, Alejandro & Tiainen, Hanna (2023). QCM-D combined with live cell imaging reveals inverse correlation between cell adhesion to tannic acid nanocoatings and serum concentration in medium .
• Zaytseva-Zotova, Daria; Singh, Simon; Haideri, Frozan; Elkafas, Nadin Abdelwahab Mohamed Abdou; Barrantes Bautista, Alejandro & Singh, Preet Bano [Vis alle 7 forfattere av denne artikkelen] (2023). Capsaicin-loaded microdroplets for the treatment of burning mouth syndrome.
• Zaytseva-Zotova, Daria (2021). Successful use of 3DLife methodology across species. [Internett]. https://www.digitallifenorway.org/research/3dlife/news/succe.
• Zaytseva-Zotova, Daria; Haslene-Hox, Hanne; Arlov, Øystein; Vikenes, Anette; Hoel, Andrea Draget & Chahal, Aman S [Vis alle 15 forfattere av denne artikkelen] (2021). Alginate Hydrogel Characteristics Regulate Dermal Fibroblasts Biology.
• Zaytseva-Zotova, Daria; Haslene-Hox, Hanne; Arlov, Øystein; Vikenes, Anette; Hoel, Andrea Draget & Chahal, Aman S [Vis alle 13 forfattere av denne artikkelen] (2020). Varying single parameters of the alginate hydrogels to design better microenvironments for fibroblasts cultivation in vitro.
• Kjesbu, Joachim Sebastian; Zaytseva-Zotova, Daria; Solheim, Ingeborg Elisabeth & Strand, Berit Løkensgard (2019). Alginate microspheres with polycationic coatings for in vitro cell cultivation​.
• Hoel, Andrea Draget; Haslene-Hox, Hanne; Arlov, Øystein; Klinkenberg, Geir; Vikenes, Anette & Åslund, Andreas [Vis alle 11 forfattere av denne artikkelen] (2019). 3DLife: Validating new high-throughput methods for 3D cell culture screening.
• Zaytseva-Zotova, Daria; Ruohola, Rita; Strand, Wenche Iren; Akbarzadeh, Anita; Haslene-Hox, Hanne & Arlov, Øystein [Vis alle 14 forfattere av denne artikkelen] (2019). Alginate hydrogels with tailored mechanical and biological properties for 3D fibroblast culture .
• Zaytseva-Zotova, Daria; Strand, Wenche Iren; Akbarzadeh, Anita; Rouhola, Rita; Haslene-Hox, Hanne & Arlov, Øystein [Vis alle 11 forfattere av denne artikkelen] (2019). Optimizing alginate gelation conditions for 3D cell culture.
• Zaytseva-Zotova, Daria; Ruohola, Rita; Strand, Wenche Iren; Akbarzadeh, Anita; Haslene-Hox, Hanne & Arlov, Øystein [Vis alle 12 forfattere av denne artikkelen] (2019). Soft alginate hydrogels modified with bioactive peptides as extracellular matrices for 3D fibroblast culture.
• Zaytseva-Zotova, Daria; Strand, Wenche Iren; Akbarzadeh, Anita; Haslene-Hox, Hanne; Arlov, Øystein & Vikenes, Anette [Vis alle 10 forfattere av denne artikkelen] (2018). Alginate-based biomimetic matrices for 3D cell culture and high throughput screening.

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