Shermin Rusthen

• Rusthen, Shermin; Kristoffersen, Anne Karin; Young, Alix; Galtung, Hilde; Petrovski, Beata & Palm, Øyvind [Vis alle 8 forfattere av denne artikkelen] (2019). Dysbiotic salivary microbiota in dry mouth and primary Sjögren’s syndrome patients. PLOS ONE. ISSN 1932-6203. 14(6), s. 1–15. doi: 10.1371/journal.pone.0218319. Fulltekst i vitenarkiv
• Tashbayev, Behzod; Rusthen, Shermin; Young, Alix; Herlofson, Bente Brokstad; Hove, Lene Hystad & Singh, Preet Bano [Vis alle 13 forfattere av denne artikkelen] (2017). Interdisciplinary, comprehensive oral and ocular evaluation of patients with primary Sjögren's syndrome. Scientific Reports. ISSN 2045-2322. 7:10761, s. 1–9. doi: 10.1038/s41598-017-10809-w. Fulltekst i vitenarkiv
• Rusthen, Shermin; Young, Alix; Herlofson, Bente Brokstad; Aqrawi, Lara Adnan; Rykke, Morten & Hove, Lene Hystad [Vis alle 9 forfattere av denne artikkelen] (2017). Oral disorders and oral health-related quality of life in patients with primary Sjögren’s Syndrome. European Journal of Oral Sciences. ISSN 0909-8836. 125(4), s. 265–271. doi: 10.1111/eos.12358. Fulltekst i vitenarkiv
• Aqrawi, Lara Adnan; Galtung, Hilde; Vestad, Beate; Øvstebø, Reidun; Thiede, Bernd & Rusthen, Shermin [Vis alle 13 forfattere av denne artikkelen] (2017). Identification of potential saliva and tear biomarkers in primary Sjögren’s syndrome, utilising the extraction of extracellular vesicles and proteomics analysis. Arthritis Research & Therapy. ISSN 1478-6354. 19(1). doi: 10.1186/s13075-017-1228-x. Fulltekst i vitenarkiv

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• Homayouni, Amin; Tashbayev, Behzod; Rusthen, Shermin; Hove, Lene Hystad; Rykke, Morten & Singh, Preet Bano [Vis alle 9 forfattere av denne artikkelen] (2018). Can saliva secretion affect oral malodour and oral health-related quality of life? Vis sammendrag

  The aim of this study was to investigate the relationship between saliva secretion, halitosis and oral health-related quality of life (HRQoL). Informed consent was obtained from 65 participants including 24 patients with primary Sjögren’s Syndrome (pSS, 53±12y), 17 patients with dry eyes and dry mouth not fulfilling the classification for pSS (non-SS-sicca, 53±11y), and 24 healthy controls (49±11y). Unstimulated (UWS) and stimulated (SWS) whole saliva secretion rates were recorded as low (hyposalivation: SWS <0.7 ml/min, UWS <0.1 ml/min) or normal (SWS >0.7 ml/min, UWS >0.1 ml/min). Volatile sulfur compounds (VSC: hydrogen sulphide-H2S, methylmercaptan-CH3SH) in mouth air were measured by gas chromatography. HRQoL was assessed using the Oral Health Impact Profile-14 (OHIP-14). Mann-Whitney test was used in data analysis (p<0.05). In general, for UWS, subjects with hyposalivation had significantly higher mean CH3SH-levels than those with normal salivation (27.339.3 vs 9.913.6 ppb). For SWS, subjects with hyposalivation had significantly higher mean H2S-levels (184.5464.8 vs 43.964.1 ppb) and CH3SH-levels (27.237.4 vs 6.58.9 ppb). Within the non-SS patient group, those with hyposalivation had significantly higher H2S-levels than those with normal salivation. In general, there were no significant differences in OHIP-scores based on VSC levels. However, within the non-SS group, those with high H2S-levels (>112 ppb) reported significantly more often that they had “difficulties relaxing due to oral problems”, and that “life has been less satisfactory due to oral problems”, than those with low H2S-levels (<112 ppb). In conclusion, hyposalivation was generally associated with increased levels of oral VSC, indicating oral malodour. Surprisingly, patients with dry eyes and dry mouth who did not fulfill the classification for pSS seemed to be more affected in their daily life than patients who fulfilled the criteria.

• Langeland, Øystein; Tashbayev, Behzod; Rusthen, Shermin; Young, Alix; Herlofson, Bente Brokstad & Hove, Lene Hystad [Vis alle 14 forfattere av denne artikkelen] (2018). Comparative Ocular and Oral Findings in Sicca Complex.
• Rusthen, Shermin; Kristoffersen, Anne Karin; Young, Alix; Galtung, Hilde; Enersen, Morten & Jensen, Janicke Liaaen (2018). The Salivary Microbiota Profile in Reduced and Normal Salivation.
• Tashbayev, Behzod; Chen, Xiangjun; Utheim, Øa; Rusthen, Shermin; Young, Alix & Herlofson, Bente Brokstad [Vis alle 14 forfattere av denne artikkelen] (2018). Primary Sjögren´s Syndrome and Non-Sjögren´s Sicca Syndrome Patients; unexpected differences in symptoms and findings of dry eye disease, dry mouth, and oral health related quality of life .
• Rusthen, Shermin; Young, Alix; Preet, Bano; Tashbayev, Behzod; Garen, Torhild Oddveig & Aqrawi, Lara A. [Vis alle 11 forfattere av denne artikkelen] (2017). Is Health-related Quality of Life Correlated to Oral Status in Primary Sjögren’s Syndrome Patients?
• Tashbayev, Behzod; Rusthen, Shermin; Chen, X; Utheim, Tor Paaske; Utheim, Øygunn Aass & Young, Alix [Vis alle 12 forfattere av denne artikkelen] (2017). Dry Mouth and Dry Eye Examinations of a Norwegian Cohort of Primary Sjögren´s Syndrome Patients.
• Jensen, Janicke Liaaen; Utheim, Øygunn Aass; Chen, Xiangjun; Thiede, Bernd; Aqrawi, Lara Adnan & Rusthen, Shermin [Vis alle 9 forfattere av denne artikkelen] (2016). Searching for Disease Biomarkers for Primary Sjögren’s Syndrome Based on Oral and Ocular Patient Examinations.
• Rusthen, Shermin; Singh, Preet Bano; Young, Alix; Aqrawi, Lara Adnan; Rykke, Morten & Hove, Lene Hystad [Vis alle 9 forfattere av denne artikkelen] (2016). Oral quality of life, salivary, gustatory and olfactory status in patients with primary Sjögren’s syndrome.
• Hove, Lene Hystad; Aqrawi, Lara Adnan; Rusthen, Shermin; Young, Alix; Rykke, Morten & Herlofson, Bente Brokstad [Vis alle 10 forfattere av denne artikkelen] (2016). Establishment of a Dry Mouth Clinic at the Faculty of Dentistry, University of Oslo, Norway.
• Young, Alix; Rusthen, Shermin; Aqrawi, Lara Adnan; Rykke, Morten; Hove, Lene Hystad & Herlofson, Bente Brokstad [Vis alle 9 forfattere av denne artikkelen] (2016). Dental health status of patients diagnosed with primary Sjögren's Syndrome. Vis sammendrag

  This clinical study aims to assess some oral health parameters in patients diagnosed with primary Sjögren’s Syndrome (pSS), and is part of a larger project studying groups of patients suffering from dry mouth. Material and methods: Twenty female pSS patients (mean age 54±12.7y) and 32 healthy controls (mean age 50±12.4y), were recruited to the study and examined at a newly established Dry Mouth Clinic at the Faculty of Dentistry, University of Oslo, after giving written consent. A questionnaire was filled out and clinical and radiological examinations were performed. Differences between the patient and control groups were calculated using t-test or Chi-squared tests. Results: Approximately 1/3 of patients considered their general and oral health as ‘poor’ or ‘very poor’. No controls considered their general health as ‘poor’ or ‘very poor’, and only 1 control considered their oral health as ‘poor’ or ‘very poor’. Ninety percent of patients and 75% of controls had visited the dentist within the last year. There was no between-group difference in the mean number of teeth present (patients 25.5±2.7; controls 26.1±3.8). The patients had higher mean caries experience: DMFT (patients: 18.0±6.45; controls 12.9±7.26, p=0.014), FT (patients: 15.35±5.77; controls 11.28±6.10, p=0.02), and D3-5T (patients: 0.60±0.94; controls: 0.28±0.58, p=0.136). Visible plaque was observed in 30% of patients and 9.4% of controls (p=0.056). Signs of gingivitis were observed in 25% of patients and 6% of controls (p=0.054). Conclusion: Compared to controls, pSS patients reported poorer general and oral health. They had significantly higher dental caries experience, and a tendency to more plaque and gingivitis. However, the pSS patients reported visiting their dentist more regularly than the controls, suggesting an awareness of the oral consequences of reduced salivary function.

• Singh, Preet Bano; Rusthen, Shermin; Aqrawi, Lara A.; Young, Alix; Rykke, Morten & Hove, Lene Hystad [Vis alle 9 forfattere av denne artikkelen] (2016). Chemosensory disorders, burning mouth sensation, and halitosis in patients with Sjögren’s syndrome .

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