Behzod Tashbayev

• Fineide, Fredrik; Tashbayev, Behzod; Elgstøen, Katja B. Prestø; Mørk Sandås, Elise; Rootwelt, Helge & Hynne, Håvard [Vis alle 12 forfattere av denne artikkelen] (2023). Tear and Saliva Metabolomics in Evaporative Dry Eye Disease in Females. Metabolites. ISSN 2218-1989. 13(11). doi: 10.3390/metabo13111125. Fulltekst i vitenarkiv
• Tashbayev, Behzod; Chen, Xiangjun & Utheim, Tor Paaske (2023). Chalazion Treatment: A Concise Review of Clinical Trials. Current Eye Research. ISSN 0271-3683. 49(2), s. 109–118. doi: 10.1080/02713683.2023.2279014.
• Hynne, Håvard; Tashbayev, Behzod; Diep, My Tien; Sødal, Anne Thea Tveit; Badian, Reza & Chen, Xiangjun [Vis alle 10 forfattere av denne artikkelen] (2022). The relationship between ocular and oral dryness in a cohort from the 65-year-old population in Norway. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-13985-6. Fulltekst i vitenarkiv Vis sammendrag

  In the present study, the relationship between dry eyes and dry mouth was explored in 150 65-year-old subjects randomly selected from the general population in Oslo, Norway. The number of drugs, including xerogenic drugs, and current and previous systemic diseases were recorded. Ocular parameters recorded were the McMonnies Dry Eye Questionnaire, the Ocular Surface Disease Index, the Schirmer I Test, tear film break-up time and ocular surface staining. The oral parameters were xerostomia frequency, Summated Xerostomia Inventory, Clinical Oral Dryness Score, and unstimulated and stimulated whole saliva. The participants with current or previous systemic diseases had significantly more ocular and oral symptoms and significantly more oral clinical findings than the participants without a history of disease. Moreover, correlation and factor analyses demonstrated an association between subjective ocular and oral parameters. A significant correlation between the total number of drugs and the presence of ocular and oral symptoms was also noted. When the participants were categorized based on their ocular symptoms, poorer values were found for the oral parameters among the participants more troubled with dry eyes. The results in the present study call for increased awareness and an interdisciplinary approach in matters related to dry eyes and dry mouth.

• Chen, Xiangjun; Badian, Reza; Hynne, Håvard; Tashbayev, Behzod; Hove, Lene Hystad & Jensen, Janicke Liaaen [Vis alle 7 forfattere av denne artikkelen] (2022). Morphology of Meibomian Glands in A 65‐Year‐Old Norwegian Population without Dry Eye Disease. Journal of Clinical Medicine. ISSN 2077-0383. 11(3). doi: 10.3390/jcm11030527. Fulltekst i vitenarkiv Vis sammendrag

  Analyses of meibography may help in the diagnosis, prevention, and management of meibomian gland dysfunction (MGD). However, there is currently a paucity of data regarding meibography analyses in the young elderly populations in the Nordic countries. In the current study, meibography of the upper and lower eyelids of 117 65-year-old residents in Oslo, Norway, who did not fulfil the diagnosis of dry eye disease (DED) were analysed. Meibomian gland (MG) dropout and tarsal areas were measured semi-automatically using ImageJ software. The relationship between morphological features of the MGs and clinical dry eye tests was examined. The median percent MG dropout was 26.1% and 40.7% in the upper and lower eyelids, respectively. There was no significant difference between males and females. None of the MG morphological parameters demonstrated significant values in discriminating abnormal dry eye symptom loads or MGD diagnosis from the normal loads. We therefore concluded that moderate MG atrophy was common among the Norwegian population of 65-year-olds without DED and showed no sexual differences. Meibography alone cannot discriminate MGD from non-MGD; thus, both morphological and functional MG tests are necessary when screening for MGD.

• Tellefsen, Sara Julie Maria; Badian, Reza; Utheim, Tor Paaske; Utheim, Øygunn Aass; Stojanovic, Aleksandar & Tashbayev, Behzod [Vis alle 9 forfattere av denne artikkelen] (2020). Sex and age differences in symptoms and signs of dry eye disease in a Norwegian cohort of patients. The ocular surface. ISSN 1542-0124. 19, s. 68–73. doi: 10.1016/j.jtos.2020.11.009.
• Tashbayev, Behzod; Yazdani, Mazyar; Arita, Reiko; Fineide, Fredrik & Utheim, Tor Paaske (2020). Intense pulsed light treatment in meibomian gland dysfunction: A concise review. The ocular surface. ISSN 1542-0124. 18(4), s. 583–594. doi: 10.1016/j.jtos.2020.06.002. Fulltekst i vitenarkiv
• Tashbayev, Behzod; Utheim, Tor Paaske; Utheim, Øygunn Aass; Ræder, Sten; Jensen, Janicke Cecilie Liaaen & Yazdani, Mazyar [Vis alle 10 forfattere av denne artikkelen] (2020). Utility of Tear Osmolarity Measurement in Diagnosis of Dry Eye Disease. Scientific Reports. ISSN 2045-2322. s. 1–7. doi: 10.1038/s41598-020-62583-x. Fulltekst i vitenarkiv
• Tashbayev, Behzod; Garen, Torhild Oddveig; Palm, Øyvind; Chen, Xiangjun; Herlofson, Bente Brokstad & Young Vik, Alix Rosslyn [Vis alle 13 forfattere av denne artikkelen] (2020). Patients with non-Sjögren's sicca report poorer general and oral health-related quality of life than patients with Sjögren's syndrome: a cross-sectional study. Scientific Reports. ISSN 2045-2322. doi: 10.1038/s41598-020-59078-0. Fulltekst i vitenarkiv
• Yazdani, Mazyar; Chen, Xiangjun; Tashbayev, Behzod; Utheim, Øygunn Aass; Ræder, Sten & Hua, Yanjun [Vis alle 10 forfattere av denne artikkelen] (2019). Evaluation of the Ocular Surface Disease Index Questionnaire as a Discriminative Test for Clinical Findings in Dry Eye Disease Patients. Current Eye Research. ISSN 0271-3683. 44(9), s. 941–947. doi: 10.1080/02713683.2019.1604972. Vis sammendrag

  Purpose: To investigate to what extent the OSDI can be utilized as a discriminative test for clinical findings. Methods: One thousand and ninety patients with dry eye disease (DED) were consecutively included and examined for osmolarity, tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface staining (OSS), Schirmer I test (ST), meibum expressibility (ME), meibum quality (MQ), and diagnosis of meibomian gland dysfunction (MGD). Receiver-operating characteristic curve (ROC) analysis considering optimum balanced sensitivity and specificity (close to 50%) was used for assessment. Results: The present study on more than 1,000 patients indicates that the OSDI in the ROC curve analysis is a poor discriminator of pathological scores for TFBUT ≤ 5 (AUC = 0.553; p = .012) and ≤10 s (AUC = 0.608; p = .002), OSS ≥ 3 (AUC = 0.54; p = .043), ST ≤ 5 (AUC = 0.550; p = .032) and ≤10 mm/5 min (AUC = 0.544; p = .016), and ME ≥ 1 (AUC = 0.594; p = <0.001). Pathological scores for osmolarity >308 and >316 mOsm/L, OPI, OSS > 1, MQ, and MGD could not be discriminated by OSDI (p > .05). Conclusion: Cut-off values for the OSDI can be defined to discriminate pathological TFBUT (≤5 and ≤10), OSS (≥3), ST (≤5 and ≤10) and ME, however, the discriminability was low. Our comprehensive study emphasises the importance of taking both symptoms and signs into account in DED management.

• Chen, Xiangjun; Aqrawi, Lara Adnan; Utheim, Tor Paaske; Tashbayev, Behzod; Utheim, Øygunn Aass & Reppe, Sjur [Vis alle 12 forfattere av denne artikkelen] (2019). Elevated cytokine levels in tears and saliva of patients with primary Sjögren's syndrome correlate with clinical ocular and oral manifestations. Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-43714-5. Fulltekst i vitenarkiv
• Aqrawi, Lara Adnan; Chen, Xiangjun; Jensen, Janicke Liaaen; Morthen, Mathias Kaurstad; Thiede, Bernd & Utheim, Øygunn Aass [Vis alle 10 forfattere av denne artikkelen] (2018). Severity of clinical dry eye manifestations influences protein expression in tear fluid of patients with primary Sjögren's syndrome. PLOS ONE. ISSN 1932-6203. 13:e0205762(10), s. 1–14. doi: 10.1371/journal.pone.0205762. Fulltekst i vitenarkiv
• Yazdani, Mazyar; Chen, Xiangjun; Tashbayev, Behzod; Utheim, Øygunn Aass; Ræder, Sten & Lagli, Neil [Vis alle 9 forfattere av denne artikkelen] (2018). Tear production levels and dry eye disease severity in a large Norwegian cohort. Current Eye Research. ISSN 0271-3683. 43(12), s. 1465–1470. doi: 10.1080/02713683.2018.1514055. Fulltekst i vitenarkiv Vis sammendrag

  Purpose: To determine if the Schirmer I test (without anesthesia) cut-off value is a predictor of dry eye severity in a large Norwegian cohort of dry eye disease (DED) patients, which are grouped into six levels of tear production. Methods: Patients (n = 1090) with DED of different etiologies received an extensive dry eye work-up: osmolarity (Osm), tear meniscus height (TMH), tear film break-up time (TFBUT), ocular protection index (OPI), ocular surface staining (OSS), Schirmer I test (ST), meibum expressibility (ME), and meibum quality (MQ). Classification of dry eye severity level (DESL) and diagnosis of meibomian gland dysfunction (MGD) were also included. The cohort was divided into six groups: below and above cut-off values of 5 (groups 1 and 2), 10 (groups 3 and 4), and 15 mm (groups 5 and 6) of ST. Mann-Whitney test and Chi-Square test were used for group comparison of parameters (p ≤ 0.05). Results: The groups 1, 3, and 5 had values indicating more severe DED than the groups 2, 4, 6 with significant difference in DESL, Osm, TFBUT, OPI, OSS, and TMH. Regardless of the choice of cut-off values, there was no statistically significant difference in ME, MQ, and MGD between groups below and above selected cut-off value. When gender difference was considered in each group, significant difference was only observed for DESL (groups 2, 4, and 5), TFBUT (groups 2, 4, and 5), OPI (groups 2 and 6), and ME (group1). Conclusions: Schirmer I is a robust discriminator for DESL, Osm, TFBUT, OPI, OSS, and TMH, but not for ME, MQ, and MGD. Patients with lower tear production levels presented with more severe DED at all three defined cut-off values. Interestingly, the differences in the mean values of DESL were minimal although statistically significant. Thus, the clinical value of different Schirmer levels appears to be limited.

• Landsend, Erlend Christoffer Sommer; Pedersen, Hilde Røgeberg; Utheim, Øygunn Aass; Xiao, Jiaxin; Adil, Muhammed Yasin & Tashbayev, Behzod [Vis alle 10 forfattere av denne artikkelen] (2018). Meibomian gland dysfunction and keratopathy are associated with dry eye disease in aniridia. British Journal of Ophthalmology. ISSN 0007-1161. s. 119–124. doi: 10.1136/bjophthalmol-2017-310927. Fulltekst i vitenarkiv Vis sammendrag

  Aims To investigate the aetiology and characteristics of dry eye disease (DED) in a Nordic cohort of patients with congenital aniridia. Methods Thirty-four Norwegian and one Danish subject with congenital aniridia and 21 healthy controls were examined. All subjects underwent an extensive dry eye examination, including evaluation of meibomian glands (MGs) by meibography, measurement of tear production and tear film osmolarity and grading of vital staining of the ocular surface. Moreover, slit-lamp biomicroscopy was undertaken, including grading of aniridia-associated keratopathy (AAK). Results Mean tear film osmolarity was significantly higher (314±11 mOsmol/L) in patients with aniridia compared with the healthy control group (303±11 mOsmol/L, p=0.002). Vital staining score was higher in the aniridia group (4.3±3.0) compared with healthy controls (2.4±1.6, p=0.02). The degree of staining correlated positively with the stage of AAK (r=0.44, p=0.008) and negatively with corneal sensitivity (r=−0.45, p=0.012). Number of expressible MGs was lower in aniridia subjects (2.9±1.6) than in controls (4.0±1.3, p=0.007). MG loss, staged from 0 to 3, was higher in the aniridia group than in the control group, both in upper eyelid (0.86±0.89 vs 0.10±0.31, p=0.001) and lower eyelid (0.94±0.73 vs 0.30±0.47, p=0.003). Computerised analyses showed thinning (p=0.004) and lower density (p<0.001) of the MGs compared with the healthy population. Conclusions Patients with congenital aniridia demonstrate increased tear film osmolarity, ocular surface staining, loss of MGs and lower MG expressibility. We conclude that meibomian gland dysfunction and keratopathy are related to development of DED in aniridia.

• Chen, Xiangjun; Utheim, Øygunn Aass; Xiao, Jiaxin; Adil, Muhammed Yasin; Stojanovic, Aleksandar & Tashbayev, Behzod [Vis alle 8 forfattere av denne artikkelen] (2017). Meibomian gland features in a Norwegian cohort of patients with primary Sjögren´s syndrome. PLOS ONE. ISSN 1932-6203. 12(9). doi: 10.1371/journal.pone.0184284. Fulltekst i vitenarkiv
• Tashbayev, Behzod; Rusthen, Shermin; Young, Alix; Herlofson, Bente Brokstad; Hove, Lene Hystad & Singh, Preet Bano [Vis alle 13 forfattere av denne artikkelen] (2017). Interdisciplinary, comprehensive oral and ocular evaluation of patients with primary Sjögren's syndrome. Scientific Reports. ISSN 2045-2322. 7:10761, s. 1–9. doi: 10.1038/s41598-017-10809-w. Fulltekst i vitenarkiv

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• Jensen, Janicke Liaaen; Chen, Xiangjun; Hynne, Håvard; Westgaard, Kristine Løken; Hove, Lene Hystad & Young, Alix [Vis alle 14 forfattere av denne artikkelen] (2019). Sjögren’s versus irradiated head-neck cancer patients: oral and ocular investigations.
• Homayouni, Amin; Tashbayev, Behzod; Rusthen, Shermin; Hove, Lene Hystad; Rykke, Morten & Singh, Preet Bano [Vis alle 9 forfattere av denne artikkelen] (2018). Can saliva secretion affect oral malodour and oral health-related quality of life? Vis sammendrag

  The aim of this study was to investigate the relationship between saliva secretion, halitosis and oral health-related quality of life (HRQoL). Informed consent was obtained from 65 participants including 24 patients with primary Sjögren’s Syndrome (pSS, 53±12y), 17 patients with dry eyes and dry mouth not fulfilling the classification for pSS (non-SS-sicca, 53±11y), and 24 healthy controls (49±11y). Unstimulated (UWS) and stimulated (SWS) whole saliva secretion rates were recorded as low (hyposalivation: SWS <0.7 ml/min, UWS <0.1 ml/min) or normal (SWS >0.7 ml/min, UWS >0.1 ml/min). Volatile sulfur compounds (VSC: hydrogen sulphide-H2S, methylmercaptan-CH3SH) in mouth air were measured by gas chromatography. HRQoL was assessed using the Oral Health Impact Profile-14 (OHIP-14). Mann-Whitney test was used in data analysis (p<0.05). In general, for UWS, subjects with hyposalivation had significantly higher mean CH3SH-levels than those with normal salivation (27.339.3 vs 9.913.6 ppb). For SWS, subjects with hyposalivation had significantly higher mean H2S-levels (184.5464.8 vs 43.964.1 ppb) and CH3SH-levels (27.237.4 vs 6.58.9 ppb). Within the non-SS patient group, those with hyposalivation had significantly higher H2S-levels than those with normal salivation. In general, there were no significant differences in OHIP-scores based on VSC levels. However, within the non-SS group, those with high H2S-levels (>112 ppb) reported significantly more often that they had “difficulties relaxing due to oral problems”, and that “life has been less satisfactory due to oral problems”, than those with low H2S-levels (<112 ppb). In conclusion, hyposalivation was generally associated with increased levels of oral VSC, indicating oral malodour. Surprisingly, patients with dry eyes and dry mouth who did not fulfill the classification for pSS seemed to be more affected in their daily life than patients who fulfilled the criteria.

• Langeland, Øystein; Tashbayev, Behzod; Rusthen, Shermin; Young, Alix; Herlofson, Bente Brokstad & Hove, Lene Hystad [Vis alle 14 forfattere av denne artikkelen] (2018). Comparative Ocular and Oral Findings in Sicca Complex.
• Hynne, Håvard; Tashbayev, Behzod; Young, Alix; Herlofson, Bente Brokstad; Hove, Lene Hystad & Rykke, Morten [Vis alle 14 forfattere av denne artikkelen] (2018). Evaluation of Dry Eye Disease, Oral Dryness and Inflammatory Cytokines in Primary Sjögren´s Syndrome.
• Tashbayev, Behzod; Chen, Xiangjun; Utheim, Øa; Rusthen, Shermin; Young, Alix & Herlofson, Bente Brokstad [Vis alle 14 forfattere av denne artikkelen] (2018). Primary Sjögren´s Syndrome and Non-Sjögren´s Sicca Syndrome Patients; unexpected differences in symptoms and findings of dry eye disease, dry mouth, and oral health related quality of life .
• Landsend, Erlend Christoffer Sommer; Pedersen, Hilde Røgeberg; Utheim, Øygunn Aass; Tashbayev, Behzod; Lagali, Neil & Dartt, Darlene Ann [Vis alle 8 forfattere av denne artikkelen] (2017). Tear Cytokine Profile in a Scandinavian Cohort of Congenital Aniridia.
• Rusthen, Shermin; Young, Alix; Preet, Bano; Tashbayev, Behzod; Garen, Torhild Oddveig & Aqrawi, Lara A. [Vis alle 11 forfattere av denne artikkelen] (2017). Is Health-related Quality of Life Correlated to Oral Status in Primary Sjögren’s Syndrome Patients?
• Tashbayev, Behzod; Rusthen, Shermin; Chen, X; Utheim, Tor Paaske; Utheim, Øygunn Aass & Young, Alix [Vis alle 12 forfattere av denne artikkelen] (2017). Dry Mouth and Dry Eye Examinations of a Norwegian Cohort of Primary Sjögren´s Syndrome Patients.

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